November 9-11 • Digital Event
    POST EVENT REPORT
    The Past, Present, and Future of 
    Microbiome-targeting Applications 
    in Nutrition
    By Lauren Bass
    Lauren Bass Growth Marketing Consulting
    www.microbiome-nutrition.com 
                                                                            Microbiome Movement - Human Nutrition Summit 
                                                   The Past, Present, and Future 
                                                   of Microbiome-targeting 
                                                   Applications in Nutrition
                                                   By Lauren Bass
                                                   Lauren Bass Growth Marketing Consulting
                                                             he industry’s preeminent         In the remainder of this report, we will 
                                                     T microbiome scientists,                 walk through the key themes and insights 
                                                             researchers, business            from the conference, touching on:
                                                   executives, and brands came together 
                                                   in Boston for the 2019 Microbiome          • the microbiome and its link to various 
                                                   Movement Human Nutrition                      chronic illnesses from food allergies to 
                                                   Conference. Sharing cutting edge              diabetes, psoriasis, IBS and more
                                                   research and actionable new insights,      •  the role of personalized nutrition in 
                                                   they built and fostered relationships         microbiome therapy
                                                   that have already been key in              •  human milk oligosaccharides (HMOs) 
       “The conference                             accelerating their work focused on diet,      and development of the infant 
       was filled with                             health and the microbiome.                    microbiome
                                                                                              •  the expansion of the microbiome 
       tons of great                               A variety of themes were covered in-          market beyond probiotics, to 
       technical                                   depth, focusing on two key areas:             prebiotics and postbiotics
       content at the                              1.  The latest developments in             Is there a Causal Relationship 
                                                     research at the intersection of          Between the Microbiome and 
       intersection of                               nutrition, the microbiome, and the       Chronic Disease?
                                                     treatment and prevention of chronic      During his talk, The Gut Microbiota, 
       industry (biotech                             disease.                                 Food Science, and Human Nutrition: 
       & consumer                                                                             A Timely Marriage, Michael Barratt, 
                                                   2.   Useful  insights from the brands      Assistant Professor, Pathology & 
       goods) and                                    successfully commercializing the         Immunology at Washington University, 
                                                     health promoting products emerging       argued that we need to move beyond 
       academia.”                                    from this research, and building the     studies of association to define causal 
                                                     microbiome market among doctors          relationships between the microbiome 
       Dan Erickson, Nestle Purina                   and consumers.                           and chronic diseases. 
                                                   www.microbiome-nutrition.com 
       Microbiome Movement - Human Nutrition Summit 
       Walking the talk, he shared the             Muriel Derrien, Senior Gut Microbiota                        “It was a great 
       experimental frameworks he is using         Scientist at Danone Nutricia Research,                      combination of 
       to demonstrate a causal relationship        and her team found that severe IBS 
       between the composition of the              has a distinct microbiota signature                    academic science, 
       microbiome and both obesity and             in humans. Not only that, in her                            entrepreneurial 
       childhood undernutrition.                   talk, Rethinking Diet from the                         development, and 
                                                   Perspective of the Gut Microbiota, 
       Similarly, Azza Gadir, Director of R&D      she walked us through some                          final translation into 
       for Seed Health, shared insights from       important experiment results:                       commercial product 
       her team’s research into the relationship 
       between the microbiome and chronic          1.  Through a clinical study her team                     all in the Human 
       illness. In her presentation, Live Microbes    demonstrated that a higher dose                        Nutrition sector.”
       Drive the Activation of Immune                 of ingested strains of probiotics was 
       Responses and Inhibit the Development          associated with higher fecal recovery.            David Kyle, Evolve Biosystems
       of Food Allergies, Gadir concludes that 
       a shared regulatory mechanism enables       2. In mice, antibiotics cause an 
       different commensal bacteria to suppress       alteration in gut microbiota 
       food allergies, indicating a potential for     following clindamycin, with an 
       microbial therapies to treat this disorder.    incomplete recovery, and that when 
                                                      the L. paracasei strain is ingested 
       Studying how the microbiome and                after the antibiotic it promotes 
       diet drive another chronic illness, IBS,       microbiota resilience.
       www.microbiome-nutrition.com 
                                                                               Microbiome Movement - Human Nutrition Summit 
       “Networking and                               The learnings from these presentations,      their personal microbiota fermentation 
       collaborating to                              plus others, exposed a number of             capabilities and offer personalized diet 
                                                     actionable insights at the forefront of      recommendations. The goal is to develop 
       move the field                                research and product development             nutritional therapies to treat and prevent 
       forward.”                                     focused on the microbiome and nutrition.     obesity, metabolic disorders, and anxiety 
                                                                                                  and depression.
       Aubrey Levitt, Postbiotics Plus               The Potential of Personalized 
                                                     Nutrition in Microbiome Therapy              Josh Stevens is the President of DayTwo, 
                                                     In his talk, A Personalized Dietary          a startup offering a food-as-medicine 
                                                     Framework for Exploiting the                 solution for personalized glycemic 
                                                     Fermentation Capabilities of a               control for people with type 2 diabetes. 
       “Good opportunity                             Patient’s Microbiota, Thomas                 From its research, DayTwo found 
       to meet scientific                            Gurry, Senior Research Associate at          that people have variable glycemic 
                                                     the University of Geneva, asked an           responses to the same foods, which are 
       leaders from the                              important question:                          driven in part by each individual’s unique 
       nutrition world,                                                                           microbiome composition. 
                                                     Can we engineer microbiota 
       and to understand                             composition and metabolic output             In his presentation, Machine Learning in 
       their needs and                               through targeted dietary interventions       the Microbiome: Providing Predictable 
                                                     to improve health outcomes?                  Personalized Nutrition based on 
       opportunities                                                                              your Gut, Stevens walked through how 
       regarding                                     Gurry’s research quantified the effect that  DayTwo uses inputs, such as microbiome 
                                                     dietary compounds - protein, saturated       profiling, blood tests, and food diaries, 
       microbome science.”                           fat, unsaturated fat, pectin inulin,         and others, and applies machine 
                                                     cellulose - could have on microbiota         learning to predict personal glycemic 
       Julius Goepp                                  composition using tightly controlled         responses to different foods. 
       Scaled Microbiomics                           feeding studies. The results showed that 
                                                     prebiotic supplementation resulted in        From this data they’re able to create 
                                                     reproducible blooms in microbiota and        personalized diets that lower glycemic 
                                                     that the same species can respond            response and have successfully helped 
       “Hoping to educate                            differently in different individuals.        patients put type 2 diabetes and 
       and be educated,                                                                           prediabetes into remission, and reduce 
                                                     When studying the metabolic output via       prescription medications. They’ve found 
       and potentially                               short-chain fatty acid production via ex-    that microbiome profiling is a more useful 
       synergize with other                          vivo framework, the results indicated that   tool to predict glycemic response than 
                                                     fermentation capabilities differ between     traditional calorie and carbohydrate 
       participants.”                                healthy people. Vesta Biosciences is         counting, because it takes the patient’s 
                                                     being built from this foundation to offer    unique traits into account, not just the 
       Momo Vuyisich, Viome                          diagnostics for patients to determine        traits of the food. 
                                                     www.microbiome-nutrition.com