ASPEN 2021 Nutrition Science & Practice Conference
   Intestinotrophic effect of a novel long-acting GLP-2 analog, 
   HM15912, in animal model for short bowel syndrome and 
          potential as monthly administration
    Jae Hyuk Choi, JinBong Lee, EunJinPark, Sung Min Bae, DaeJinKim, Young HoonKim, In Young Choi
            Sr. manager / Bio Discovery Team
         HanmiPharm. Co., Ltd., Seoul, Republic of Korea
                                                Disclosures
          Employee of Hanmi Pharm. Co., Ltd.
   ed.
   All Rights Reserv
   ition.
   Nutr
   Enteral 
   and 
   r Parenteral 
   fo
    
   merican Society
   A
    
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   ASPEN 
   © 2021 
                                                  What GLP-2 is
                                  Proglucagon                      33 amino acids     Various biological actions
                                      Glicentin      GLP-1    IP2    GLP-2                   ↓ Food intake
                                   GRPP    OXM
    ed.                                                                                   ↓ Bone resorption
    All Rights Reserv                                                                     ↓ Gastric motility & 
    ition.                                                                                     secretion
    Nutr
    Enteral 
    and Intestinal L cell                                                               ↑ Energy absorption & 
                                                                                        mucosal morphology
    r Parenteral                                                                        - Intestinal growth
    fo
                                                                                        - Mucosal integrity
    merican Society
    A
     
    |
    ASPEN 
    © 2021 
                                                  What GLP-2 is
                                  Proglucagon                      33 amino acids     Various biological actions
                                      Glicentin      GLP-1    IP2    GLP-2                   ↓ Food intake
                                   GRPP    OXM
    ed.                                                                                   ↓ Bone resorption
    All Rights Reserv                                                                     ↓ Gastric motility & 
    ition.                                “Crypt cell proliferation via GLP-2/IGF-1 axis”      secretion
    Nutr
    Enteral 
    and Intestinal L cell                                                               ↑ Energy absorption & 
                                                                                        mucosal morphology
    r Parenteral                                                                        - Intestinal growth
    fo
                                                                                        - Mucosal integrity
    merican Society
    A
     
    |
    ASPEN 
    © 2021