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Sheet 1: Description
| UNIVERSITY OF WASHINGTON STRATEGIC ANALYSIS, RESEARCH & TRAINING (START) CENTER | ||||
| REPORT TO THE BILL & MELINDA GATES FOUNDATION | ||||
| PRODUCED BY WIYEH A, ARCHER H, DELAWALLA M, JACKSON E, STEWART B. 8/3/2020 | ||||
| Subscribe on the Digest website: | ||||
| http://uwstartcenter.org/publication-digests/mnch-covid-research-digest/ | ||||
| Inclusion Criteria | Research articles on SARS-CoV-2 in pregnant women and children under 5 years of age, including topics on mother-to-child transmission and the effect of COVID-19 on routine maternal and child health care. Commentaries, editorials, and reports are also included, as well as articles on other coronaviruses if relevant to COVID-19. Clinical trials relevant to SARS-CoV-2 in pregnant women and children under 5 years of age. |
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| Non-English Articles | Non-English articles identified through searches without a full-text translation were included if deemed relevant by title and/or abstract, but were not further reviewed for this digest. | |||
| Notes on Article Review | Blue fields below are filled out for all articles via title and abstract review. Green fields were filled out only for articles with primary data (i.e., studies, case series), which were also briefly reviewed at full text level to identify if they reported certain measures. | |||
| Notes on Clinical Trials | Unlike the articles, the Clinical Trials sheet will be maintained week to week, with a weekly update to status as relevant and the addition of newly announced trials. Most fields are as exported from the WHO Clinical Trials Database, and not corrected or modified. | |||
| Field Descriptions ("Articles" Sheet) | ||||
| TITLE | Publication Title | |||
| ABSTRACT | Abstract, if available | |||
| PUBLICATION DATE | Date of publication | |||
| ADDED TO DATABASE | Date of online publication to database (i.e. PubMed, Embase) | |||
| URL | URL | |||
| COUNTRY | For primary data articles, study location; as available from reviews and commentary. If >3 countries listed, or countries not specified, listed as "multi-country" | |||
| ARTICLE TYPE | Studies are characterized by study design; other types include reviews and editorials/commentaries/guidance. Note case studies or case series are categorized as descriptive studies. | |||
| AUTHORS | As available from publication | |||
| JOURNAL | As available from publication | |||
| PUBLICATION YEAR | As available from publication | |||
| SOURCE TYPE | Peer-reviewed source, pre-print source, or grey literature | |||
| LANGUAGE (IF NON-ENG) |
Language of publication if article is not in English. Articles not available in English not reviewed beyond title and abstract if English translation of abstract is available. | |||
| DOI | As available from publication | |||
| PREG/NEO | Does it address this population? "Yes"/blank | |||
| CU5 | Does it address this population? "Yes"/blank | |||
| MTCT | Does it address this topic? "Yes"/blank | |||
| MNCH IMPACT | Does it address this topic? (e.g., COVID-19 impact on MNCH programs such as ANC or EPI) "Yes"/blank | |||
| LMIC | What population does the article address? LMIC, HIC, both (LMIC/HIC) | |||
| STUDY SIZE | Free text of details on study population. | |||
| PREG/NEO - CLINICAL PRESENTATION | Measurement field: “Yes”/blank if references the following: | |||
| • Studies that report clinical presentation of COVID-19 (usually case studies/series) | ||||
| PREG/NEO - BURDEN | Measurement field: “Yes”/blank if references the following: | |||
| • Studies that report incidence, prevalence, DALYs of pregnant women and/or neonates (e.g., population number of cases and deaths) | ||||
| PREG/NEO - RISK FACTOR | Measurement field: “Yes”/blank if references the following: | |||
| • Studies on risk factors for COVID-19 infection (e.g., nutritional status, microbiome, gestational age, environmental exposures/behaviors that modify risk, exposure to hospitals treating COVID-19 patients during labor & delivery) | ||||
| PREG/NEO - OUTCOMES | Measurement field: “Yes”/blank if references the following: | |||
| • Studies on birth outcomes (e.g., miscarriage, still birth, preterm birth) | ||||
| • Studies on maternal outcomes (e.g., preeclampsia) | ||||
| PREG/NEO - MANAGEMENT/VACCINES | Measurement field: “Yes”/blank if references the following | |||
| • Studies on management of COVID-19 infections and symptom alleviation among pregnant women and/or neonates | ||||
| • Studies on vaccines including pregnant women and/or neonates | ||||
| CU5 - INFANT | Measurement field: “Yes”/blank if references the following: | |||
| • Studies including infants (i.e., ages >28 days to 1 year) | ||||
| CU5 - CLINICAL PRESENTATION | Measurement field: “Yes”/blank if references the following: | |||
| • Studies that report clinical presentation of COVID (usually case studies/series)) | ||||
| CU5 - BURDEN | Measurement field: “Yes”/blank if references the following: | |||
| • Studies that report incidence, prevalence, DALYs of children under 5 years (population number of cases and deaths) | ||||
| CU5 - RISK FACTORS | Measurement field: “Yes”/blank if references the following: | |||
| • Studies on risk factors for children under 5 years (e.g., severe or moderate acute malnutrition, preterm birth, low birth weight, environmental exposures or behaviors that modify risk) | ||||
| CU5 - MANAGEMENT/VACCINES | Measurement field: “Yes”/blank if references the following: | |||
| • Studies on Management of COVID-19 infections and symptom alleviation among children under 5 years | ||||
| • Studies on vaccines including children under 5 years | ||||
| MTCT - RISK | Measurement field: “Yes”/blank if references the following: | |||
| • Studies on vertical transmission and transmission via breastmilk | ||||
| MTCT - ANTIBODIES | Measurement field: “Yes”/blank if references the following: | |||
| • Studies on passive maternal antibody transfer through breastmilk | ||||
| MNCH IMPACT - PROG PREG/NEO | Measurement field: “Yes”/blank if references the following: | |||
| • Studies about the impact of COVID-19 on MNCH programs that serve pregnant women, mothers, and neonates (e.g., ANC, delivery) | ||||
| MNCH IMPACT - PROG CU5 | Measurement field: “Yes”/blank if references the following: | |||
| • Studies about the impact of COVID-19 on MNCH programs that serve children under 5 years (e.g., EPI) | ||||
| INTERVENTION NOTES | Free text of additional details on COVID-19 vaccination or other preventive intervention, if available | |||
| MODEL NOTES | Free text of additional details on modeling, if available | |||
| SPECIAL INTEREST AREA | Free text addition of articles on areas of interest to the client. These currently includes breast milk/breastfeeding articles, and articles related to maternal and child mental health. These articles are also presented in seperate sheets titled " Breast milk - Breast feeding" and " Mental health" | |||
| BACKLOG | As of 4/20/20, in addition to articles identified in the current week, a backlog of literature through 12/1/2019 will be added in batches. Please see this column to differentiate. | |||
| Field Descriptions ("Clinical Trials" Sheet) | ||||
| UPDATED | Date last updated by START Team; previously identified studies will be updated periodically for changes in dates or status. | |||
| TRIAL NAME | Trial title/name | |||
| TARGET POPULATION | Pregnant women or children under 5 years (CU5); as study populations may have a large range of ages, any study that stated inclusion of ages 0-4 years was included. | |||
| INTERVENTIONS | As stated in study record as of "updated" date | |||
| OUTCOME MEASURES | As stated in study record as of "updated" date | |||
| INCLUSION CRITERIA | As stated in study record as of "updated" date | |||
| EXCLUSION CRITERIA | As stated in study record as of "updated" date | |||
| START DATE | Listed start date of trial | |||
| COMPLETION DATE | Listed completion date of trial | |||
| REGISTRATION DATE | Date of trial registration | |||
| URL | URL | |||
| SOURCE REGISTER | Original trial registry | |||
| COUNTRY | Country of study location | |||
| STUDY TYPE | As stated in study record as of "updated" date | |||
| STUDY DESIGN | As stated in study record as of "updated" date | |||
| PRIMARY SPONSOR | As stated in study record as of "updated" date | |||
| MINIMUM AGE | As stated in study record as of "updated" date | |||
| MAXIMUM AGE | As stated in study record as of "updated" date | |||
| STATUS | As stated in study record as of "updated" date | |||
| TRIAL NUMBER | Trial identifier; registry-specific | |||
| ENROLMENT DATE | As stated in study record as of "updated" date | |||
| TARGET SIZE | Number enrolled as stated in study record as of "updated" date | |||
| PHASES | Current phase as stated in study record as of "updated" date | |||
| STUDY LOCATIONS | As stated in study record as of "updated" date | |||
| TITLE | ABSTRACT | PUBLICATION DATE | ADDED TO DATABASE | URL | COUNTRY | ARTICLE TYPE | AUTHORS | JOURNAL | PUBLICATION YEAR | TYPE | DOI | LANGUAGE |
PREG/NEO | CU5 | MTCT | MNCH IMPACT | LMIC | STUDY SIZE | PREG/NEO - CLINICAL PRESENTATION | PREG/NEO - BURDEN | PREG/NEO - RISK FACTOR | PREG/NEO - OUTCOMES | PREG/NEO - MANAGEMENT/ VACCINES | CU5 - INFANTS | CU5 - CLINICAL PRESENTATION | CU5 - BURDEN | CU5 - RISK FACTORS | CU5 - MANAGEMENT/ VACCINES | MTCT - RISK | MTCT - ANTIBODIES | MNCH IMPACT - PROG PREG/NEO | MNCH IMPACT - PROG CU5 | INTERVENTION NOTES | MODEL NOTES | SPECIAL INTEREST AREA | BACKLOG |
| Prolonged Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in an Obstetric Patient With Antibody Seroconversion | BACKGROUND: There is a growing understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) in the general population. The unique immunology of pregnancy may result in variations from the reported course of disease. CASE: A 27-year-old primigravid woman presented with mild COVID-19 symptoms at 28 2/7 weeks of gestation, testing positive for SARS-CoV-2 infection by nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR). Antibody seroconversion was detected at 36 6/7 weeks of gestation. She presented for delivery at 38 1/7 weeks of gestation, and her SARS-CoV-2 RT-PCR test result was positive. Severe acute respiratory syndrome coronavirus 2 RNA remained detectable 34 days postpartum and 104 days from her initial positive test. CONCLUSION: Prolonged viral shedding of SARS-CoV RNA may occur in the pregnant patient. If prevalent, this complicates the interpretation of a positive SARS-CoV-2 RT-PCR test result in the asymptomatic gravid patient. |
7/21/2020 | 7/24/2020 | https://pubmed.ncbi.nlm.nih.gov/32701763/ | USA | Descriptive study | Molina LP, Chow SK, Nickel A, Love JE. | Obstet Gynecol | 2020 | Peer-reviewed | 10.1097/AOG.0000000000004086 | English | Yes | Yes | HIC | 1 | Yes | Yes | Yes | Yes | Yes | Breast milk | Current week | |||||||||||||
| Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission | Background: There is a growing need for information regarding maternal and neonatal outcomes during coronavirus pandemic. In this study, a comprehensive investigation was done regarding the possibility of vertical transmission using the available data in the literature. Methods: A systematic search was conducted using electronic databases, including PubMed, Scopus, Web of Science, Embase, and Scholar. All studies containing infected COVID-19 pregnant women who had given birth were included, and the search was done up to April 14, 2020. Results: Overall, 21 articles were reviewed, and clinical characteristics of 90 pregnant patients and 92 neonates born to mothers infected with COVID-19 were reviewed. The most common symptoms included fever, cough, and dyspnea. The main laboratory findings included leukocytosis, lymphopenia, thrombocytopenia, and elevated C-reactive protein. The most commonly reported complications were preterm labor and fetal distress. Three mothers were admitted to ICU and required mechanical ventilation; among them, one died, and one was on extracorporeal membrane oxygenation. Overall, 86 neonates were tested for the possibility of vertical transmission and 82 cases were negative in RT-PCR, while 4 were positive. Out of 92 neonates, one died, and one was born dead. Nineteen patients reported having no symptoms, while breathing problems and pneumonia were reported as the most common neonatal complications. Conclusion: There were no differences in the clinical characteristics of pregnant women and non-pregnant COVID-19 patients. COVID-19 infection has caused higher incidence of fetal distress and premature labor in pregnant women. Although the possibility of vertical transmission in infected pregnant women is rare, four neonates' test results for COVID-19 infection were positive in this review. |
7/1/2020 | 7/21/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362089/ | Multicountry | Review | Ashraf MA, Keshavarz P, Hosseinpour P, Erfani A, Roshanshad A, Pourdast A, Nowrouzi-Sohrabi P, Chaichian S, Poordast T. | J Reprod Infertil | 2020 | Peer-reviewed | None available | English | Yes | Yes | LMIC/HIC | 90 pregnant patients and 92 neonates born to mothers infected with COVID-19 | Yes | Yes | Yes | Yes | Yes | Yes | Breast milk | Current week | ||||||||||||
| Consensus on Recommendations for Safe Sexual Activity during the COVID-19 Coronavirus Pandemic | Abstract Sexual activity offers numerous advantages for physical and mental health but maintains inherent risks in a pandemic situation, such as the current one caused by SARS-CoV-2. A group of experts from the Spanish Association of Sexuality and Mental Health (AESexSAME) has reached a consensus on recommendations to maintain lower-risk sexual activity, depending on one's clinical and partner situations, based on the current knowledge of SARS-CoV-2. Different situations are included in the recommendations: a sexual partner passing quarantine without any symptoms, a sexual partner that has not passed quarantine, a sexual partner with some suspicious symptoms of COVID-19, a positive sexual partner with COVID-19, a pregnant sexual partner, a health professional partner in contact with COVID-19 patients, and people without a sexual partner. The main recommendations include returning to engaging in safe sex after quarantine is over (28 days based on the duration one can carry SARS-CoV-2, or 33 days for those who are >60 years old) and all parties are asymptomatic. In all other cases (for those under quarantine, those with some clinical symptoms, health professionals in contact with COVID-19 patients, and during pregnancy), abstaining from coital/oral/anal sex, substituting it with masturbatory or virtual sexual activity to provide maximum protection from the contagion, and increasing the benefits inherent to sexual activity are recommended. For persons without a partner, not initiating sexual activity with a sporadic partner is strongly recommended. |
7/20/2020 | 7/24/2020 | https://pubmed.ncbi.nlm.nih.gov/32698369/ | Not applicable | Editorial/commentary/guidance | Cabello F, Sánchez F, Farré JM, Montejo AL. | J Clin Med | 2020 | Peer-reviewed | 10.3390/jcm9072297 | English | Yes | Yes | HIC | Not applicable | Yes | Yes | Breast milk/ Breast feeding | Current week | ||||||||||||||||
| Fetal deaths in pregnancies with SARS-CoV-2 infection in Brazil: A case series | Background There are few reports of miscarriages or stillbirths in women infected with SARS-CoV-2. We present five consecutive cases of fetal death (≥12 weeks) without other putative causes in women with laboratory-confirmed (RT-PCR) COVID-19 managed in a single Brazilian institution. Case series All five women were outpatients with mild or moderate forms of COVID-19 and were not taking any medication. Four were nulliparous, all were overweight or obese, and none had any comorbidities or pregnancy complications that could contribute to fetal demise. Fetal death occurred at 21–38 weeks of gestation, on COVID-days 1–22. SARS-Cov-2 was detected by RT-PCR in amniotic fluid in one case and in placental specimens in two cases. All five women had acute chorioamnionitis on placental histology, massive deposition of fibrin, mixed intervillitis/villitis, and intense neutrophil and lymphocyte infiltration. One fetus had neutrophils inside alveolar spaces, suggestive of fetal infection. Conclusions These five cases of fetal demise in women with confirmed COVID-19 without any other significant clinical or obstetric disorders suggest that fetal death can be an outcome of SARS-CoV-2 infection in pregnancy. The intense placental inflammatory reaction in all five cases raises the possibility of a direct effect of SARS-CoV-2 on the placenta. |
7/27/2020 | 7/25/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354271/ | Brazil | Descriptive study | Richtmann R, Torloni MR, Oyamada Otani AR, Levi JE, Crema Tobara M, de Almeida Silva C, Dias L, Miglioli-Galv√£o L, Martins Silva P, Macoto Kondo M. | Case Rep Womens Health | 2020 | Peer-reviewed | 10.1016/j.crwh.2020.e00243 | English | Yes | Yes | LMIC | 5 | Yes | Yes | Yes | Yes | Yes | Yes | Current week | |||||||||||||
| Simulating the effect of school closure during COVID-19 outbreaks in Ontario, Canada | Background: The province of Ontario, Canada, has instituted indefinite school closures (SC) as well as other social distancing measures to mitigate the impact of the novel coronavirus disease 2019 (COVID-19) pandemic. We sought to evaluate the effect of SC on reducing attack rate and the need for critical care during COVID-19 outbreaks, while considering scenarios with concurrent implementation of self-isolation (SI) of symptomatic cases. Methods: We developed an age-structured agent-based simulation model and parameterized it with the demographics of Ontario stratified by age and the latest estimates of COVID-19 epidemiologic characteristics. Disease transmission was simulated within and between different age groups by considering inter- and intra-group contact patterns. The effect of SC of varying durations on the overall attack rate, magnitude and peak time of the outbreak, and requirement for intensive care unit (ICU) admission in the population was estimated. Secondly, the effect of concurrent community-based voluntary SI of symptomatic COVID-19 cases was assessed. Results: SC reduced attack rates in the range of 7.2-12.7% when the duration of SC increased from 3 to 16 weeks, when contacts among school children were restricted by 60-80%, and in the absence of SI by mildly symptomatic persons. Depending on the scenario, the overall reduction in ICU admissions attributed to SC throughout the outbreak ranged from 3.3 to 6.7%. When SI of mildly symptomatic persons was included and practiced by 20%, the reduction of attack rate and ICU admissions exceeded 6.3% and 9.1% (on average), respectively, in the corresponding scenarios. Conclusion: Our results indicate that SC may have limited impact on reducing the burden of COVID-19 without measures to interrupt the chain of transmission during both pre-symptomatic and symptomatic stages. While highlighting the importance of SI, our findings indicate the need for better understanding of the epidemiologic characteristics of emerging diseases on the effectiveness of social distancing measures. |
7/24/2020 | 7/26/2020 | https://pubmed.ncbi.nlm.nih.gov/32709232/ | Canada | Modelling study | Abdollahi E, Haworth-Brockman M, Keynan Y, Langley JM, Moghadas SM. | BMC Med | 2020 | Peer-reviewed | 10.1186/s12916-020-01705-8 | English | Yes | Yes | HIC | Not applicable | Yes | Yes | Current week | |||||||||||||||||
| Syndemic Perspectives to Guide Black Maternal Health Research and Prevention During the COVID-19 Pandemic | The coronavirus 2019 (COVID-19) pandemic and related policies have led to an unequal distribution of morbidity and mortality in the U.S. For Black women and birthing people, endemic vulnerabilities and disparities may exacerbate deleterious COVID-19 impacts. Historical and ongoing macro-level policies and forces over time have induced disproportionately higher rates of maternal morbidity and mortality among Black women and birthing people, and contemporary macroeconomic and healthcare policies and factors continue to hold particular consequence. These factors induce detrimental psychological, health, and behavioral responses that contribute to maternal health disparities. The COVID-19 pandemic is likely to disproportionately impact Black women and birthing people, as policy responses have failed to account for the their unique socioeconomic and healthcare contexts. The resulting consequences may form a ‘vicious cycle’, with upstream impacts that exacerbate upstream macro-level policies and forces that can further perpetuate the clustering of maternal morbidity and mortality in this population. Understanding the impacts of COVID-19 among Black women and birthing people requires theoretical frameworks that can sufficiently conceptualize their multi-level, interacting, and dynamic nature. Thus, we advocate for the proliferation of syndemic perspectives to guide maternal disparities research and prevention during the COVID-19 pandemic. These perspectives can enable a holistic and nuanced understanding of the intersection of endemic and COVID-19-specific vulnerabilities and disparities experienced by Black women and birthing people. Syndemic-informed research can then lead to impactful multi-level prevention strategies that simultaneously tackle both endemic and COVID-19-specific factors and outcomes that lead to the clustering of vulnerabilities and disparities over time. | 7/21/2020 | 7/23/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372977/ | USA | Editorial/commentary/guidance | Lemke MK, Brown KK. | Matern Child Health J | 2020 | Peer-reviewed | 10.1007/s10995-020-02983-7 | English | Yes | Yes | HIC | Not applicable | Yes | Yes | Current week | |||||||||||||||||
| Urticaria in an Infant with SARS-CoV-2 Positivity | None available | 7/22/2020 | 7/23/2020 | https://pubmed.ncbi.nlm.nih.gov/32697027/ | Italy | Descriptive study | Proietti I, Mambrin A, Bernardini N, Tolino E, Balduzzi V, Maddalena P, Marchesiello A, Michelini S, Volpe S, Skroza N, Potenza C. | Dermatol Ther | 2020 | Peer-reviewed | 10.1111/dth.14043 | English | Yes | HIC | 1 | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Recommendations and management of hyperglycaemia in pregnancy during COVID-19 pandemic in Italy | Many specialists use the remote management of people with chronic disease as diabetes, but structured management protocols have not been developed yet. The COVID-19 pandemic has given a big boost to the use of telemedicine, as it allows to maintain the physical distance, essential to the containment of contagion having regular health contact. Encouraging results related to the use of telemedicine in women with hyperglycaemia in pregnancy, have been recently published. It is well known that hyperglycaemia alters the immune response to infections, that inflammation, in turn, worsens glycaemic control and that any form of hyperglycaemia in pregnancy (HIP) has effects not only on the mother but also on development of the foetus. Therefore, the Italian Diabetes and Pregnancy Study Group, together with a group of experts, developed these recommendations in order to guide physicians in the management of HIP, providing specific diagnostic, therapeutic and assistance pathways (PDTAs) for the COVID-19 emergency. Three detailed PDTAs were developed, for type 1, type 2 and gestational diabetes. | 7/22/2020 | 7/26/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375279/ | Italy | Editorial/commentary/guidance | Torlone E, Angela Sculli M, Bonomo M, Di Benedetto A, Di Cianni G, Festa C, Formoso G, Lapolla A, Mannino D, Napoli A, Scavini M, Succurro E, Vitacolonna E, Sciacca L. | Diabetes Res Clin Pract | 2020 | Peer-reviewed | 10.1016/j.diabres.2020.108345 | English | Yes | HIC | Not applicable | Yes | Current week | |||||||||||||||||||
| Foreseeing a worsening of pediatric malnutrition following SARS-CoV-2 in low and middle-income countries such as Pakistan | None available | 7/19/2020 | 7/23/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368840/ | Pakistan | Editorial/commentary/guidance | Sajid MI, Tariq J, Waheed AA, Dur-E-Najaf, Balouch SS, Abaidullah S. | J Pediatr Nurs | 2020 | Peer-reviewed | 10.1016/j.pedn.2020.06.016 | English | Yes | LMIC | Not applicable | Yes | Current week | |||||||||||||||||||
| Systematic SARS-CoV-2 screening at hospital admission in children:a French prospective multicenter study | To assess the relevance of systematic SARS-CoV-2 screening of all children admitted to hospital, we conducted a prospective multicenter study including 438 consecutive hospitalized children. A symptom-based SARS-CoV-2 testing strategy failed to identify 45% (95%CI [24; 68]) of hospitalized children infected by SARS-CoV-2. To limit intra-hospital transmission, a systematic screening of children admitted to hospital should be considered. | 7/25/2020 | 7/26/2020 | https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa1044/5876373 | France | Descriptive study | Poline J, Gaschignard J, Leblanc C, Madhi F, Foucaud E, Nattes E, Faye A, Bonacorsi S, Mariani P, Varon E, Smati-Lafarge M, Caseris M, Basmaci R, Lachaume N, Ouldali N. | Clin Infect Dis | 2020 | Peer-reviewed | 10.1093/cid/ciaa1044 | English | Yes | HIC | 438 children included with SARS Covid positive in 22 of them | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Clinical management of coronavirus disease 2019 (COVID-19) in pregnancy: recommendations of WAPM-World Association of Perinatal Medicine | These guidelines follow the mission of the World Association of Perinatal Medicine, which brings together groups and individuals throughout the world with the goal of improving outcomes of maternal, fetal and neonatal (perinatal) patients. Guidelines for auditing, evaluation, and clinical care in perinatal medicine enable physicians diagnose, treat and follow-up of COVID-19-exposed pregnant women. These guidelines are based on quality evidence in the peer review literature as well as the experience of perinatal expert throughout the world. Physicians are advised to apply these guidelines to the local realities which they face. We plan to update these guidelines as new evidence become available. | 7/21/2020 | 7/22/2020 | https://pubmed.ncbi.nlm.nih.gov/32692708/ | Not applicable | Editorial/commentary/guidance | Api O, Sen C, Debska M, Saccone G, D'Antonio F, Volpe N, Yayla M, Esin S, Turan S, Kurjak A, Chervenak F. | J Perinat Med | 2020 | Peer-reviewed | 10.1515/jpm-2020-0265 | English | Yes | LMIC/HIC | Not applicable | Yes | Yes | Yes | Yes | Yes | Breast milk/ Breast feeding | Current week | ||||||||||||||
| Pediatric Coronavirus Disease-19 (COVID-19): Meta-analyzing Literature Versus Natural History | None available | 7/24/2020 | 7/26/2020 | https://pubmed.ncbi.nlm.nih.gov/32710533/ | Not applicable | Editorial/commentary/guidance | Menon PR. | Indian Pediatr | 2020 | Peer-reviewed | None available | English | Yes | LMIC/HIC | Not applicable | Yes | Yes | Current week | ||||||||||||||||||
| High rates of stillbirth and preterm delivery in women with covid-19 and the efficacy of ECMO in pregnancy | None available | 7/27/2020 | 7/29/2020 | https://pubmed.ncbi.nlm.nih.gov/32718936/ | Not applicable | Editorial/commentary/guidance | Kingston EV. | BMJ | 2020 | Peer-reviewed | 10.1136/bmj.m2921 | English | Yes | LMIC/HIC | Not applicable | Yes | Yes | Extracorporeal membrane oxygenation | Current week | |||||||||||||||||
| Emergency Department utilisation by vulnerable paediatric populations during COVID-19 pandemic | Objective: To determine if changes to community-based services have effected paediatric ED attendances for mental health issues and neonates during the COVID-19 pandemic METHODS: Analysis of total presentations, presentations with a mental health diagnoses, and presentation of neonates during the early stages of the pandemic compared with the previous year for 4 Victorian hospitals. Results: There was a 47.2% decrease in total presentations compared with 2019, with a 35% increase in mental health diagnoses and a 2% increase in neonatal presentations. Conclusion: Vulnerable paediatric patients are seeking care elsewhere during the pandemic due to the closure of community services. This article is protected by copyright. All rights reserved. |
7/23/2020 | 7/25/2020 | https://pubmed.ncbi.nlm.nih.gov/32705775/ | Australia | Descriptive study | Cheek JA, Craig SS, West A, Lewena S, Hiscock H. | Emerg Med Australas | 2020 | Peer-reviewed | 10.1111/1742-6723.13598 | English | Yes | Yes | HIC | Not applicable | Current week | |||||||||||||||||||
| Fatal cerebral infarct in a child with COVID-19 | None available | 7/23/2020 | 7/25/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376273/ | USA | Descriptive study | Kihira S, Morgenstern PF, Raynes H, Naidich TP, Belani P. | Pediatr Radiol | 2020 | Peer-reviewed | 10.1007/s00247-020-04779-x | English | Yes | HIC | 1 | Yes | Yes | Yes | Current week | |||||||||||||||||
| Letter to the Editor: Recommendations for the Care of Pediatric Orthopaedic Patients During the COVID-19 Pandemic | None available | 7/22/2020 | 7/24/2020 | https://journals.lww.com/jaaos/Citation/9000/Letter_to_the_Editor__Recommendations_for_the_Care.99054.aspx | Not applicable | Editorial/commentary/guidance | O ºBeirne J, de Pelligrin M. | J Am Acad Orthop Surg | 2020 | Peer-reviewed | 10.5435/JAAOS-D-20-00489 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Reply to Letter to the Editor: Recommendations for the Care of Pediatric Orthopaedic Patients During the COVID-19 Pandemic | None available | 7/22/2020 | 7/24/2020 | https://pubmed.ncbi.nlm.nih.gov/32701685/ | Not applicable | Editorial/commentary/guidance | Schaeffer EK, Farrell S, Mulpuri K. | J Am Acad Orthop Surg | 2020 | Peer-reviewed | 10.5435/JAAOS-D-20-00743 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Ketoacidosis in Children and Adolescents With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic in Germany | This study uses diabetes registry data to compare the frequency of diabetic ketoacidosis (DKA) in children and adolescents at time of type 1 diabetes diagnosis in Germany during the first 2 months of the coronavirus disease 2019 (COVID-19) pandemic vs the same time period in 2018 and 2019. | 7/20/2020 | 7/24/2020 | https://pubmed.ncbi.nlm.nih.gov/32702751/ | Germany | Descriptive study | Kamrath C, Mönkemöller K, Biester T, Rohrer TR, Warncke K, Hammersen J, Holl RW. | JAMA | 2020 | Peer-reviewed | 10.1001/jama.2020.13445 | English | Yes | HIC | 135 children under 6 years | Current week | ||||||||||||||||||||
| Acute lymphoblastic leukemia onset in a 3-year-old child with COVID-19 | None available | 7/24/2020 | 7/25/2020 | https://pubmed.ncbi.nlm.nih.gov/32706512/ | Italy | Descriptive study | Marcia M, Vania B, Pruccoli G, Vallero SG, Barisone E, Scolfaro C, Fagioli F. | Pediatr Blood Cancer | 2020 | Peer-reviewed | 10.1002/pbc.28423 | English | Yes | HIC | 1 | Yes | Yes | Current week | ||||||||||||||||||
| Challenges for pediatric hematology oncology in Pakistan during coronavirus pandemic | None available | 7/25/2020 | 7/26/2020 | https://pubmed.ncbi.nlm.nih.gov/32710696/ | Pakistan | Cross-sectional study | Rahat Ul-Ain, Faizan M. | Pediatr Blood Cancer | 2020 | Peer-reviewed | 10.1002/pbc.28600 | English | Yes | LMIC | 53 pediatric hematologists‐oncologists across the country responded | Current week | ||||||||||||||||||||
| Disproportionate impact of COVID-19 among pregnant and postpartum Black Women in Brazil through structural racism lens | None available | 7/28/2020 | 7/29/2020 | https://pubmed.ncbi.nlm.nih.gov/32719866/ | Brazil | Descriptive study | Santos DS, Menezes MO, Andreucci CB, Nakamura-Pereira M, Knobel R, Katz L, Salgado HO, de Amorim MMR, Takemoto MLS. | Clin Infect Dis | 2020 | Peer-reviewed | 10.1093/cid/ciaa1066 | English | Yes | Yes | LMIC | 669 | Yes | Yes | Yes | Yes | Yes | Yes | Current week | |||||||||||||
| COVID-19 in Different Age Groups of Children: Initial Impression from Integrated Disease Surveillance Programme (IDSP) under National Centre for Disease Control (NCDC) | None available | 7/23/2020 | 7/24/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376071/ | India | Descriptive study | Kulkarni SV, Chauhan H. | Indian J Pediatr | 2020 | Peer-reviewed | 10.1007/s12098-020-03457-y | English | Yes | LMIC | Not applicable | Yes | Yes | Current week | ||||||||||||||||||
| Do We Really Need to Isolate All Children with COVID-19 in Healthcare Facilities? | None available | 7/27/2020 | 7/28/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384904/ | Multicountry | Editorial/commentary/guidance | Lee J, Kim KH, Kang HM, Kim JH. | J Korean Med Sci | 2020 | Peer-reviewed | 10.3346/jkms.2020.35.e277 | English | Yes | LMIC/HIC | Not applicable | Yes | Yes | Current week | ||||||||||||||||||
| Kawasaki-like disease in children with COVID-19: A hypothesis | We previously made the hypothesis that STING contributes to COVID-19. The present review detail new arguments for over-activation of STING pathways in COVID-19, following the description of hyper-coagulability and Kawasaki-like diseases in children. Indeed, Kawasaki disease is induced by overreaction of innate cells following exposition to various viruses, including herpes viruses which trigger STING. It predisposes to diffuse vasculitis and aneurysms, whereas STING is over-expressed in arterial aneurisms. The redness at the inoculation site of bacillus Calmette-Guérin, a specific feature of Kawasaki disease, is reproduced by activation of the STING pathway, which is inhibited upstream by aspirin, intravenous immunoglobulins, and Vitamin-D. SARS-CoV2 binding to ACE2 can lead to excessive angiotensin II signaling, which activates the STING pathway in mice. Over-activation of the STING-pathway promotes hyper-coagulability through release of interferon-β and tissue factor by monocytes-macrophages. Aspirin and dipyridamole, besides their anti-platelet activity, also reduce tissue factor procoagulant activity, and aspirin inhibits the STING pathway upstream of STING. Aspirin and dipyridamole may be used, in combination with drugs blocking downstream the activation of the STING pathway, like inhibitors of IL-6R and JAK/STAT pathways. The risk of bleeding should be low as bleeding has not been reported in severe COVID-19 patients. | 6/23/2020 | 7/27/2020 | https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1785336 | Not applicable | Review | Amirfakhryan H. | Medical Hypotheses (2020) 143 Article Number: 110117. Date of Publication: 1 Oct 2020 | 2020 | Peer-reviewed | 10.1016/j.mehy.2020.110117 | English | Yes | LMIC/HIC | Not applicable | Yes | Yes | Current week | ||||||||||||||||||
| Erratum: Routine vaccination during covid-19 pandemic response (The BMJ (2020) 369 (m2393) DOI: 10.1136/bmj.m2392) | None available | 6/16/2020 | https://pubmed.ncbi.nlm.nih.gov/32546575/ | UK | Editorial/commentary/guidance | Sonia Saxena, Helen Skirrow, Helen Bedford | The BMJ (2020) 369 Article Number: m2435. Date of Publication: 18 Jun 2020 | 2020 | Peer-reviewed | 10.1136/bmj.m2435 | English | Yes | HIC | Not applicable | Yes | Current week | ||||||||||||||||||||
| Where do we go from here? A child rights-based response to COVID-19 | None available | 6/15/2020 | 7/22/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299026/ | Not applicable | Editorial/commentary/guidance | Raman S., Harries M., Nathawad R., Kyeremateng R., Seth R., Lonne B., Zwi K., Spencer N.J., Goldhagen J., Mercer R., Rubio B., Tamburlini G., Goldfeld S., Woolfenden S., Gander S., Oberg C. | BMJ Paediatrics Open (2020) 4:1 Article Number: e000714. Date of Publication: 15 Jun 2020 | 2020 | Peer-reviewed | 10.1136/bmjpo-2020-000714 | English | Yes | LMIC/HIC | Not applicable | Yes | Current week | |||||||||||||||||||
| COVID-19 in pregnant women and neonates: A systematic review of the literature with quality assessment of the studies | The SARS-CoV-2 virus emerged in December 2019 and then spread globally. Little is still known about the impact of COVID-19 on pregnant women and neonates. A review of the literature was performed according to the PRISMA guideline recommendations, searching the MEDLINE and EMBASE databases. Studies' quality assessments were performed using the JBI Critical Appraisal Checklist. A total of 37 studies were included, involving 275 pregnant women with COVID-19 and 248 neonates. The majority of pregnant women presented with mild to moderate symptoms, only 10 were admitted in the ICU, and one died. Two stillbirths were reported and the incidence of prematurity was 28%. Sixteen neonates were tested positive for SARS-CoV-2 by RT-PCR, and nine of them were born from mothers infected during pregnancy. Neonatal outcomes were generally good: all the affected neonates recovered. RT-PCR for SARS-CoV-2 yielded negative results on amniotic fluid, vaginal/cervical fluids, placenta tissue, and breast milk samples. SARS-CoV-2 infection in pregnant women appeared associated with mild or moderate disease in most cases, with a low morbidity and mortality rate. The outcomes of neonates born from infected women were mainly favorable, although neonates at risk should be closely monitored. Further studies are needed to investigate the possibility of vertical transmission. | 6/18/2020 | 7/27/2020 | https://pubmed.ncbi.nlm.nih.gov/32570959/ | Multicountry | Review | Trippella G., Ciarcià M., Ferrari M., Buzzatti C., Maccora I., Azzari C., Dani C., Galli L., Chiappini E. | Pathogens (2020) 9:6 (1-29) Article Number: 485. Date of Publication: 1 Jun 2020 | 2020 | Peer-reviewed | 10.3390/pathogens9060485 | English | Yes | Yes | LMIC/HIC | 275 pregnant women and 248 neonates | Yes | Yes | Yes | Yes | Yes | Yes | Breast milk/ Breast feeding | Current week | ||||||||||||
| Coronavirus, its neurologic manifestations, and complications | Context: We are going to face an epidemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus in our country. The main manifestation of this viral infection is respiratory and cardiovascular; however, up-to-date knowledge of its probable neurologic complications is highly needed. Evidence Acquisition: To provide up-to-date information on neurologic manifestation on coronaviruses, we concisely reviewed the neurologic manifestations and their complications. Using the keywords, coronavirus, corona, human coronaviruses (HCoVs), SARS, Middle East respiratory syndrome-related (MERS), coronavirus disease 2019 (COVID-19), manifestations, complications, and neurologic, all the relevant articles were retrieved from PubMed, reviewed, and critically analyzed. Results: Although the main clinical manifestation of human coronaviruses is respiratory involvement and the main cause of death is acute respiratory failure, extra respiratory manifestations such as neurologic findings have been reported. Fortunately, the neurologic manifestations in COVID-19 have not been reported yet. Conclusions: We need well-designed studies to monitor neurologic manifestations of COVID-19 in adults and children. |
4/14/2020 | 7/27/2020 | https://sites.kowsarpub.com/ijp/articles/102569.html | Not applicable | Review | Ashrafi M.R., Azizimalamiri R., Badv R.S., Tavasoli A.R., Nikkhah A., Montazerlotfelahi H., Vafaee-Shahi M., Heidari M. | Iranian Journal of Pediatrics (2020) 30:2 (1-4) Article Number: e102569. Date of Publication: 1 Apr 2020 | 2020 | Peer-reviewed | 10.5812/IJP.102569 | English | Yes | LMIC/HIC | Not applicable | Yes | Current week | |||||||||||||||||||
| A qualitative study on the psychological needs of hospitalized newborns’ parents during covid-19 outbreak in China | Background: As the 2019 novel coronavirus disease (COVID-19) emerged in China, the parents of hospitalized neonatal patients commonly endure more psychological stress compared to the general population, which probably originated from not staying with their children, inconvenience of daily life, and financial crisis. Objectives: We investigated the psychological needs of hospitalized newborns’ parents during the COVID-19 outbreak in Chongqing, China. Methods: The phenomenological method was used to conduct this qualitative research. In-depth interviews were carried out on 14 parents of hospitalized newborns by the same interview based on a semi-structured interview outlines. The interviews were audio-taped, transcribed, and analyzed using Colaizzi’s 7-step analysis method. Results: All the subjects’ children were admitted to a neonatal ward within the first two weeks of initiating the first-level response to COVID-19 in Chongqing, China. The in-depth interviews identified five themes regarding the parents’ primary psychological needs, which included urgent demand for timely up-to-date information about the children’s condition, demand for psychological and emotional support, reducing the inconvenience caused by the epidemic outbreak, claim for protective information after discharge, demand for financial support. Conclusions: Based on the parents’ needs, the medical staff should actively communicate with the parents, effectively provide emotional and financial support, and convenience. Such support could be helpful to relieve the parents’ psychological stress. |
4/11/2020 | 7/27/2020 | https://sites.kowsarpub.com/ijp/articles/102748.html | China | Qualitative study | Fan J., Zhou M., Wei L., Fu L., Zhang X., Shi Y. | Iranian Journal of Pediatrics (2020) 30:2 (1-7) Article Number: e102748. Date of Publication: 1 Apr 2020 | 2020 | Peer-reviewed | 10.5812/IJP.102748 | English | Yes | Yes | LMIC | 14 parents of hospitalized newborns | Mental health | Current week | ||||||||||||||||||
| Telemedicine for Women’s Health During COVID-19 Pandemic in India: A Short Commentary and Important Practice Points for Obstetricians and Gynaecologists | Background/purpose of study In view of restrictions on patients because of COVID-19 pandemic, face-to-face consultations are difficult. This short commentary tells us about the feasibility of telemedicine in this scenario in obstetrics and gynaecology. Methods The database from our teleconsultation application (Apollo 247 and Askapollo) was analysed to assess feasibility of telemedicine and to design a triage pathway to reduce hospital visits for non-emergency situations and also to identify emergency cases without delay during this lockdown phase. Existing guidelines by Ministry of Health and Family Welfare (MOHFW), Government of India, were accessed. Results This was a single-doctor experience of 375 consultations done over 65 days. We also designed a triage pathway for obstetrics and gynaecology cases, and we discussed general practice for obstetricians and gynaecologists with its utility and limitations. Conclusion Telemedicine has provided us the opportunity to manage women health problems and pregnancy concerns during this pandemic of COVID-19, except a few instances where face-to-face consultation or hospital visit is must. If we implement the triage pathway, we can minimize the risk of exposure for both patients and healthcare teams during COVID-19 pandemic. |
7/16/2020 | 7/24/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364737/ | India | Descriptive study | Bindra V. | Journal of Obstetrics and Gynecology of India (2020). Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1007/s13224-020-01346-0 | English | Yes | LMIC | 375 consultations | Yes | Current week | |||||||||||||||||||
| Coping with COVID Crisis | Emergence of the deadly corona virus infection took place in Wuhan in China in December last year. It soon spread to all countries and became a pandemic. India’s first case of COVID 19 was confirmed in Kerala’s Thrissur district on 30 January 2020. Ever since, our lives have changed and we are facing numerous difficulties. This editorial will take you through these difficulties faced by us at practice and in life in general. It presents a brief account of the impact of COVID 19 on functioning of this journal. We have compiled quality articles on COVID in a special section of this issue. This editorial also presents the highlights of these articles along with editorial comments. It contains lessons learned from original research on 141 covid positive pregnant women. It also covers issues faced by obstetricians like taking informed consent, lactation management, and safety of computed tomography imaging in pregnancy and newly introduced rapid testing strategies. It delves into the most sensitive issue of mental health of health care workers, economic crisis and takes a look at the way forward. We sincerely hope that this editorial is useful to our readers in their practice to cope up with this unforeseen crisis situation. | 7/24/2020 | 7/24/2020 | https://link.springer.com/article/10.1007/s13224-020-01358-w | India | Editorial/commentary/guidance | Khadilkar S. | Journal of Obstetrics and Gynecology of India (2020). Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1007/s13224-020-01358-w | English | Yes | Yes | Yes | LMIC | Not applicable | Yes | Yes | Yes | Yes | Yes | Breast milk/ Breast feeding | Current week | ||||||||||||
| Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals | None available | 6/22/2020 | 7/23/2020 | https://www-sciencedirect-com.offcampus.lib.washington.edu/science/article/pii/S2589933320301063 | USA | Editorial/commentary/guidance | Hirshberg J.S., Stout M.J., Raghuraman N. | American Journal of Obstetrics and Gynecology MFM (2020) Article Number: 100162. Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1016/j.ajogmf.2020.100162 | English | Yes | HIC | Not applicable | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| A clinical management protocol for COVID-19 infection in pregnant women | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has caused a large global outbreak and has had a major impact on health systems and societies worldwide. The generation of knowledge about the disease has occurred almost as fast as its global expansion. Very few studies have reported on the effects of the infection on maternal health, since its onset. The mother and foetus do not seem to be at particularly high risk. Nevertheless, obstetrics and maternal-foetal medicine practice have made profound changes in order to adapt to the pandemic. In addition, there are aspects specific to COVID-19 and gestation that should be known by specialists. In this review an evidenced-based protocol is presented for the management of COVID-19 in pregnancy. | 7/23/2020 | 7/23/2020 | https://www.embase.com/a/#/search/results?subaction=viewrecord&rid=11&page=1&id=L2007074415 | Not applicable | Editorial/commentary/guidance | Valdés-Bango M., Meler E., Cobo T., Hernández S., Caballero A., García F., Ribera L., Guirado L., Ferrer P., Salvia D., Figueras F., Palacio M., Goncé A., López M. | Clinica e Investigacion en Ginecologia y Obstetricia (2020). Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1016/j.gine.2020.06.014 | Spanish | Yes | LMIC/HIC | Not applicable | Yes | Yes | Current week | ||||||||||||||||||
| Why children are less likely to contract COVID-19 infection than adults? | None available | 6/19/2020 | 7/24/2020 | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2020;volume=11;issue=1;spage=74;epage=74;aulast=Assadi | Not applicable | Editorial/commentary/guidance | Assadi F. | International Journal of Preventive Medicine (2020) 11:1 Article Number: 287177. Date of Publication: 1 Jan 2020 | 2020 | Peer-reviewed | 10.4103/ijpvm.IJPVM_199_20 | English | Yes | LMIC/HIC | Not applicable | Yes | Yes | Current week | ||||||||||||||||||
| Transmission of SARS-CoV-2 by Children | Background: Six months into the COVID-19 pandemic, children appear largely spared from the direct effects of disease, suggesting age as an important predictor of infection and severity. They remain, however, impacted by far-reaching public health interventions. One crucial question often posed is whether children generally transmit SARS-CoV-2 effectively. Methods: We assessed the components of transmission and the different study designs and considerations necessary for valid assessment of transmission dynamics. We searched for published evidence about transmission of SARS-CoV-2 by children employing a narrative review methodology through 25 June, 2020. Results: Transmission dynamics must be studied in repre - sentative pediatric populations with a combination of study designs including rigorous epidemiological studies (e.g. in households, schools, daycares, clinical settings) and laboratory studies while taking into account the social and socio-economic contexts. Viral load (VL) estimates from representative pediatric samples of infected children are missing so far. Currently available evidence suggests that the secondary attack rate stratified by age of the infector is lower for children, however this age pattern needs to be better quantified and understood. Conclusion: A generalizable pediatric evidence base is urgently needed to inform policy making now, later when facing potential subsequent waves, and extending through a future in which endemicity alongside vaccination may become the enduring reality. |
7/21/2020 | 7/25/2020 | https://www.aerzteblatt.de/int/archive/article/214818 | Multicountry | Review | Merckx J, Labrecque JA, Kaufman JS. | Dtsch Arztebl Int | 2020 | Peer-reviewed | 10.3238/arztebl.2020.0553 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Perinatal management of SARS-CoV-2 infection in a level III University Hospital | Over the past 4 months, SARS-CoV-2 pandemic has spread all over the world. The lack of understanding of this pandemic epidemiological characteristics, clinical implications and long term consequences have raised concern among healthcare workers. Pregnant women and newborns are a particularly worrisome population since data referring to real infection impact in these patients are scarce and management controversial. We report on the perinatal management of the first consecutive ten mother-infant dyads of SARS-CoV-2 infection complicated pregnancy. All mothers were included in newborn management planning prior to delivery and decided on separation from their newborns; nine decided on postponing breastfeeding until SARS-CoV-2 negativity while maintaining lactation stimulation. No evidence of vertical transmission was found (all NP swab and bronchial secretions SARS-CoV-2 RT-PCR were negative). No newborn developed clinical evidence of infection. In the face of current scientific uncertainty, decisions of perinatal management, such as mother-infant separation and breastfeeding, must involve parents in a process of shared decision making. | 7/23/2020 | 7/24/2020 | https://www.tandfonline.com/doi/abs/10.1080/14767058.2020.1786526?journalCode=ijmf20 | Portugal | Descriptive study | Pissarra S, Ros√°rio M, Moucho M, Soares H. | J Matern Fetal Neonatal Med | 2020 | Peer-reviewed | 10.1080/14767058.2020.1786526 | English | Yes | Yes | HIC | 10 mother-neonate dyads | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| Perinatal transmission with SARS-CoV-2 and route of pregnancy termination: a narrative review | Objective: Analyze newborns diagnosed with SARS-CoV-2 performed with RT-PCR at birth or during the first days of birth and to look for an association with the route of birth. Methods: We conducted a comprehensive literature search for newborns diagnosed with COVID-19 using PubMed, LILACS and Google scholar until May 15, 2020, looking for published articles with pregnancy, vertical transmission, intrauterine transmission, neonates, delivery. Results: There were found 10 articles with a total of 15 newborn infected with SARS-CoV-2 according to positive PCR at birth or in the first days of birth. Eleven newborn birth by cesarean section and 4 vaginally. Of the 11 cases with cesarean section, two presented premature rupture of the membranes. Seven newborns developed pneumonia, of which two had ruptured membranes and one was born by vaginal delivery. Conclusion: This review shows that there is perinatal or neonatal infection with SARS-CoV-2 by finding a positive PCR in the first days of birth. In addition, that there is more possibility of neonatal infection if the birth is vaginal or if there is premature rupture of the membranes before cesarean section. Vaginal delivery and premature rupture of membranes should be considered as risk factors for perinatal infection. Keywords: SARS-COV-2; cesarean section; perinatal infection; vaginal delivery; vertical transmission. |
7/26/2020 | 7/28/2020 | https://www.tandfonline.com/doi/full/10.1080/14767058.2020.1788533 | Multicountry | Review | Vigil-De Gracia P, Luo C, Epifanio Malpassi R. | J Matern Fetal Neonatal Med | 2020 | Peer-reviewed | 10.1080/14767058.2020.1788533 | English | Yes | Yes | LMIC/HIC | Not applicable | Current week | |||||||||||||||||||
| Children and COVID-19: microbiological and immunological insights | Since its first description in China, Sars‐CoV‐2 has spread worldwide being declared a pandemic by the World Health Organization. More than 10.3 million people have been infected and more than 506.000 people died. However, Sars‐CoV‐2 had a lower impact on the pediatric population. Only about 1‐2% of infected people are children and few deaths under the age of 14 are described so far. In this article, we discuss microbiological and immunological characteristics of Sars‐CoV‐2 infection in children highlighting main differences from adult Sars‐CoV‐2 infection. This article is protected by copyright. All rights reserved. |
7/25/2020 | 7/26/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24978 | Not applicable | Review | Buonsenso D, Sali M, Pata D, De Rose C, Sanguinetti M, Valentini P, Delogu G. | Pediatr Pulmonol | 2020 | Peer-reviewed | 10.1002/ppul.24978 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Insight into the Pediatric and Adult Dichotomy of COVID-19: Age-Related Differences in the Immune Response to SARS-CoV-2 infection | The difference in morbidity and mortality between adult and pediatric COVID‐19 infections is dramatic. Understanding pediatric‐specific acute and delayed immune responses to SARS‐CoV‐2 is critical for the development of vaccination strategies, immune‐targeted therapies, and treatment and prevention of MIS‐C. The goal of this review is to highlight research developments in understanding of the immune responses to SARS‐CoV‐2 infections, with a specific focus on age‐related immune responses. This article is protected by copyright. All rights reserved. |
7/25/2020 | 7/26/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24981 | Not applicable | Review | Fialkowski A, Gernez Y, Arya P, Weinacht KG, Bernard Kinane T, Yonker LM. | Pediatr Pulmonol | 2020 | Peer-reviewed | 10.1002/ppul.24981 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Version 1 | Objective: To provide guidance on the management of Multisystem Inflammatory Syndrome in Children (MIS-C), a condition characterized by fever, inflammation, and multiorgan dysfunction that manifests late in the course of SARS-CoV-2 infection. The Task Force also provided recommendations for children with hyperinflammation during COVID-19, the acute, infectious phase of SARS-CoV-2 infection. Methods: The Task Force was composed of 9 pediatric rheumatologists, 2 adult rheumatologists, 2 pediatric cardiologists, 2 pediatric infectious disease specialists, and 1 pediatric critical care physician. Preliminary statements addressing clinical questions related to MIS-C and hyperinflammation in COVID-19 were developed based on evidence reports. Consensus was built through a modified Delphi process that involved 2 rounds of anonymous voting and 2 webinars. A 9-point scale was used to determine the appropriateness of each statement (1-3, inappropriate; 4-6, uncertain; 7-9, appropriate), and consensus was rated as low (L), moderate (M), or high (H) based on dispersion of the votes along the numeric scale. Approved guidance statements had to be classified as appropriate with moderate or high levels of consensus, which were pre-specified prior to voting. Results: A total of 128 statements were approved by the Task Force, which were refined into 40 final guidance statements accompanied by a flow diagram depicting the diagnostic pathway for MIS-C. Conclusion: Our understanding of SARS-CoV-2-related syndromes in the pediatric population continues to evolve. This guidance document reflects currently available evidence coupled with expert opinion but is meant to be modified as additional data become available. Keywords: COVID-19; MIS-C; SARS-CoV-2; pediatrics. |
7/23/2020 | 7/25/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1002/art.41454 | Not applicable | Editorial/commentary/guidance | Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, F Son MB, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ. | Arthritis Rheumatol | 2020 | Peer-reviewed | 10.1002/art.41454 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Third Trimester Placentas of SARS-CoV-2-Positive Women: Histomorphology, including Viral Immunohistochemistry and in Situ Hybridization | Aims The wide‐variety of affected organ‐systems associated with SARS‐CoV‐2 infection highlights the need for tissue‐specific evaluation. We compared placentas from SARS‐CoV‐2‐positive and negative women in our hospital in New York City, which became the epicenter of the COVID‐19 pandemic in March 2020. While some limited studies have been published on placentas from SARS‐CoV‐2‐positive women to date, this study, in addition to describing histomorphology, utilizes in‐situ hybridization (ISH) for the S‐gene encoding the spike‐protein and immunohistochemistry (IHC) with the monoclonal‐SARS‐CoV‐2 spike‐antibody 1A9 for placental evaluation. Methods and Results In this study, 51 singleton, third‐trimester placentas from SARS‐CoV‐2‐positive women and 25 singleton, third‐trimester placentas from SARS‐CoV‐2‐negative women were examined histomorphologically using the Amsterdam Criteria as well as with ISH and/or IHC. Corresponding clinical findings and neonatal outcomes also were recorded. While no specific histomorphologic changes related to SARS‐CoV‐2 were noted in the placentas, evidence of maternal/fetal vascular malperfusion was identified, with placentas from SARS‐CoV‐2‐positive women significantly more likely to show villous agglutination (p=0.003) and subchorionic thrombi (p=0.026) than placentas from SARS‐CoV‐2‐negative women. No evidence of direct viral involvement was identified using ISH and IHC. Conclusions In this study, third trimester placentas from SARS‐CoV‐2‐positive women were more likely to show evidence of maternal/fetal vascular malperfusion; however, no evidence of direct viral involvement or vertical transmission was noted by ISH and IHC. |
7/21/2020 | 7/22/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1111/his.14215 | USA | Cross-sectional study | Smithgall MC, Liu-Jarin X, Hamele-Bena D, Cimic A, Mourad M, Debelenko L, Chen X. | Histopathology | 2020 | Peer-reviewed | 10.1111/his.14215 | English | Yes | Yes | HIC | 51 placentas from SARS-COV-2 positive women and 25 placentas from SARS-COV-2 negative women | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| Successful Maternal and Fetal Outcomes in COVID-19 Pregnant Women: An Institutional Approach | BACKGROUND: Novel Coronavirus 2019 (COVID-19) has been defined as a pandemic infecting millions of individuals with a significantly high mortality and morbidity rate. Treatment and management for pregnant patients infected with COVID-19 has been poorly described in the literature. Furthermore, vertical transmission of COVID-19 to the fetus has been poorly described. The purpose of this case series is to present 3 patients in their trimester who underwent emergent cesarean sections and were successfully managed in the intensive care unit. CASE REPORT: We present the cases of 3 patients diagnosed with COVID-19 via RT-PCR in their third trimester of pregnancy. All patients underwent emergent cesarean sections and were managed on mechanical ventilation in the intensive care unit and eventually discharged in stable condition. CONCLUSIONS: Early cesarean section and aggressive management with mechanical ventilation has been shown to be very beneficial for mothers diagnosed with COVID-19 and their infants. All 3 patients were successfully extubated, and all 3 infants tested negative for COVID-19, suggesting no vertical transmission; although, further studies are needed to confirm this finding. |
7/27/2020 | 7/28/2020 | https://www.amjcaserep.com/download/index/idArt/925513 | USA | Descriptive study | Douedi S, Albayati A, Alfraji N, Mazahir U, Costanzo E. | Am J Case Rep | 2020 | Peer-reviewed | 10.12659/AJCR.925513 | English | Yes | Yes | HIC | 3 pregnant women | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| Predicting the Impact of COVID-19 and the Potential Impact of the Public Health Response on Disease Burden in Uganda | The COVID-19 pandemic and public health "lockdown" responses in sub-Saharan Africa, including Uganda, are now widely reported. Although the impact of COVID-19 on African populations has been relatively light, it is feared that redirecting focus and prioritization of health systems to fight COVID-19 may have an impact on access to non-COVID-19 diseases. We applied age-based COVID-19 mortality data from China to the population structures of Uganda and non-African countries with previously established outbreaks, comparing theoretical mortality and disability-adjusted life years (DALYs) lost. We then predicted the impact of possible scenarios of the COVID-19 public health response on morbidity and mortality for HIV/AIDS, malaria, and maternal health in Uganda. Based on population age structure alone, Uganda is predicted to have a relatively low COVID-19 burden compared with an equivalent transmission in comparison countries, with 12% of the mortality and 19% of the lost DALYs predicted for an equivalent transmission in Italy. By contrast, scenarios of the impact of the public health response on malaria and HIV/AIDS predict additional disease burdens outweighing that predicted from extensive SARS-CoV-2 transmission. Emerging disease data from Uganda suggest that such deterioration already may be occurring. The results predict a relatively low COVID-19 impact on Uganda associated with its young population, with a high risk of negative impact on non-COVID-19 disease burden from a prolonged lockdown response. This may reverse hard-won gains in addressing fundamental vulnerabilities in women and children's health, and underlines the importance of tailoring COVID-19 responses according to population structure and local disease vulnerabilities. | 7/23/2020 | 7/25/2020 | http://www.ajtmh.org/docserver/fulltext/10.4269/ajtmh.20-0546/tpmd200546.pdf?expires=1596071821&id=id&accname=guest&checksum=3E60EFC0772A32C788A5DA2AFF47432B | Uganda | Modelling study | Bell D, Hansen KS, Kiragga AN, Kambugu A, Kissa J, Mbonye AK. | Am J Trop Med Hyg | 2020 | Peer-reviewed | 10.4269/ajtmh.20-0546 | English | Yes | Yes | LMIC | Population of Uganda | Yes | Current week | ||||||||||||||||||
| Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children | Background: Pediatric SARS-CoV-2 infection can be complicated by a dangerous hyperinflammatory condition termed multisystem inflammatory syndrome in children (MIS-C). The clinical and immunologic spectrum of MIS-C and its relationship to other inflammatory conditions of childhood have not been studied in detail. Methods: We retrospectively studied confirmed cases of MIS-C at our institution from March to June 2020. The clinical characteristics, laboratory studies and treatment response were collected. Data were compared with historic cohorts of Kawasaki disease (KD) and macrophage activation syndrome (MAS). Results: Twenty-eight patients fulfilled the case definition of MIS-C. Median age at presentation was 9 years (range 1 month to 17 years); 50% of patients had pre-existing conditions. All patients had laboratory confirmation of SARS-CoV-2 infection. Seventeen patients (61%) required intensive care, including 7 patients (25%) requiring inotrope support. Seven patients (25%) met criteria for complete or incomplete KD and coronary abnormalities were found in 6 cases. Lymphopenia, thrombocytopenia, and elevation in inflammatory markers, D-dimer, B-type natriuretic peptide, IL-6 and IL-10 levels were common but not ubiquitous. Cytopenias distinguished MIS-C from KD and the degree of hyperferritinemia and pattern of cytokine production differed between MIS-C and MAS. Immunomodulatory therapy given to MIS-C patients included IVIG (71%), corticosteroids (61%) and anakinra (18%). Clinical and laboratory improvement were observed in all cases, including 6 cases that did not require immunomodulatory therapy. No mortality was recorded in this cohort. Conclusion: MIS-C encompasses a broad phenotypic spectrum with clinical and laboratory features distinct from Kawasaki disease and macrophage activation syndrome. Funding: This work was supported by the National Institute of Health / National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K08-AR074562 (PYL), K08-AR AR073339 (LAH), R01-AR065538, R01-AR073201 and P30-AR070253 (PAN); National Institute of Allergy and Infectious Diseases 5T32AI007512-34 (JL, JR, TB, AAN and RWN); Rheumatology Research Foundation Investigator Awards (PYL and LAH) and Medical Education Award (JSH); Boston Children's Hospital Faculty Career Development Awards (PYL and LAH), the McCance Family Foundation (JWN), and the Samara Jan Turkel Center (JC, RPS, MBS). Keywords: COVID-19; Clinical practice; Immunology. |
7/23/2020 | 7/24/2020 | https://www.jci.org/articles/view/141113/pdf | USA | Descriptive study | Lee PY, Day-Lewis M, Henderson LA, Friedman K, Lo J, Roberts JE, Lo MS, Platt CD, Chou J, Hoyt KJ, Baker AL, Banzon T, Chang MH, Cohen E, de Ferranti S, Dionne A, Habiballah S, Halyabar O, Hausmann JS, Hazen M, Janssen E, Meidan E, Nelson RW, Nguyen AA, Sundel RP, Dedeoglu F, Nigrovic PA, Newburger JW, Son MBF. | J Clin Invest | 2020 | Peer-reviewed | 10.1172/JCI141113 | English | Yes | HIC | 28 patients (ages 1 month to 17 years) | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ? | Severe Acute Respiratory Syndrome-Coronavirus-2 is responsible for the current pandemic that has led to more than 10 million confirmed cases of Coronavirus Disease-19 (COVID-19) and over 500,000 deaths worldwide (4 July 2020). Virus-mediated injury to multiple organs, mainly the respiratory tract, activation of immune response with the release of pro-inflammatory cytokines, and overactivation of the coagulation cascade and platelet aggregation leading to micro- and macrovascular thrombosis are the main pathological features of COVID-19. Empirical multidrug therapeutic approaches to treat COVID-19 are currently used with extremely uncertain outcomes, and many others are being tested in clinical trials. Acetylsalicylic acid (ASA) has both anti-inflammatory and antithrombotic effects. In addition, a significant ASA-mediated antiviral activity against DNA and RNA viruses, including different human coronaviruses, has been documented. The use of ASA in patients with different types of infections has been associated with reduced thrombo-inflammation and lower rates of clinical complications and in-hospital mortality. However, safety issues related both to the risk of bleeding and to that of developing rare but serious liver and brain damage mostly among children (i.e., Reye's syndrome) should be considered. Hence, whether ASA might be a safe and reasonable therapeutic candidate to be tested in clinical trials involving adults with COVID-19 deserves further attention. In this review we provide a critical appraisal of current evidence on the anti-inflammatory, antithrombotic, and antiviral effects of ASA, from both a pre-clinical and a clinical perspective. In addition, the potential benefits and risks of use of ASA have been put in the context of the adult-restricted COVID-19 population. | 7/23/2020 | 7/25/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376326/ | Not applicable | Review | Bianconi V, Violi F, Fallarino F, Pignatelli P, Sahebkar A, Pirro M. | Drugs | 2020 | Peer-reviewed | 10.1007/s40265-020-01365-1 | English | Yes | Yes | LMIC/HIC | Not applicable | Current week | |||||||||||||||||||
| Radiological Findings of COVID-19 in Children: A Systematic Review and Meta-Analysis | Background: The majority of the children with SARS-CoV-2 infection present with respiratory symptoms, hence various chest imaging modalities have been used in the management. Knowledge about the radiological findings of coronavirus disease (COVID-19) in children is limited. Hence, we systematically synthesized the available data that will help in better management of COVID-19 in children. Methods: Four different electronic databases (MEDLINE, EMBASE, Web of Science and CENTRAL) were searched for articles reporting radiological findings in children with COVID-19. Studies reporting thoracic radiological findings of COVID-19 in patients aged <19 years were included. A random-effect meta-analysis (wherever feasible) was performed to provide pooled estimates of various findings. Results: A total of 1984 records were screened of which forty-six studies (923 patients) fulfilled the eligibility criteria and were included in this systematic review. A chest computed tomography (CT) scan was the most frequently used imaging modality. While one-third of the patients had normal scans, a significant proportion (19%) of clinically asymptomatic children had radiological abnormalities too. Unilateral lung involvement (55%) was frequent when compared with bilateral and ground-glass opacities were the most frequent (40%) definitive radiological findings. Other common radiological findings were non-specific patchy shadows (44%), consolidation (23%), halo sign (26%), pulmonary nodules and prominent bronchovascular marking. Interstitial infiltration being the most frequent lung ultrasound finding. Conclusion: CT scan is the most frequently used imaging modality for COVID-19 in children and can detect pneumonia before the appearance of clinical symptoms. Undefined patchy shadows, grand-glass opacities and consolidation are commonly observed imaging findings in COVID-19 pneumonia. Keywords: COVID-19; computed tomography; ground-glass opacity; imaging; lung ultrasound; pneumonia. |
7/21/2020 | 7/22/2020 | https://academic.oup.com/tropej/article/doi/10.1093/tropej/fmaa045/5874434 | Multicountry | Meta-analysis | Kumar J, Meena J, Yadav A, Yadav J. | J Trop Pediatr | 2020 | Peer-reviewed | 10.1093/tropej/fmaa045 | English | Yes | LMIC/HIC | 46 studies | Yes | Current week | |||||||||||||||||||
| COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis | In less than four months, the total of confirmed cases of COVID-19 was 1,684,833 worldwide. Outcomes among the public of pregnant women with COVID-19 are still unclear. We performed a systematic review and meta-analysis to analyze whether COVID-19 in pregnant women is related to premature birth and birth weight, and to summarize the diagnostic results of neonates born to mothers with COVID-19 for investigating the possibility of vertical transmission. Searches were performed in PubMed, Scopus, LILACS, Web of Science, Google Scholar, Preprints, bioRxiv, and medRxiv. We used the odds ratio (OR) and mean difference (MD) as measure of analysis. Summary estimates were calculated using random effects models. 38 studies were included; data from 279 women were analyzed; 60 patients were diagnosed with COVID-19. The meta-analysis showed no significant association between COVID-19 and preterm delivery (OR = 2.25; 95%CI: 0.96, 5.31; p = 0.06; I² = 0%). No significant relationship was found between birth weight and COVID-19 (MD = -124.16; 95%CI: -260.54, 12.22; p = 0.07; I² = 0%). Among 432 newborns, 10 were reported with positive results for early SARS-CoV-2. Due to the characteristics of the studies, the level of evidence of this meta-analysis was considered very low. COVID-19 in pregnant women may not be associated with the occurrence of preterm deliveries or the birth weight of the newborn children, however the evidence to date is very uncertain. A few reports suggest vertical transmission of SARS-CoV-2 to newborn is possible, but evidence is still uncertain. | 7/17/2020 | 7/23/2020 | https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2020000702001&lng=en&nrm=iso&tlng=en | Multicountry | Meta-analysis | Melo GC, Ara√∫jo KCGM. | Cad Saude Publica | 2020 | Peer-reviewed | 10.1590/0102-311x00087320 | English | Yes | Yes | LMIC/HIC | 38 studies, 279 women | Yes | Yes | Current week | |||||||||||||||||
| Vertical transmission of SARS CoV-2: a systematic review | Objective: The aim of this study is to review the current evidence on the vertical transmission of SARS CoV-2. Methods: Combination of the following keywords; COVID-19, SARS CoV-2, placenta, vertical transmission, intrauterine infection, breast milk were searched in databases. Results: In the 50 studies included, 17 newborns testing positive for SARS CoV-2 by RT-PCR were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated. Eight placental tissues testing positive for the virus were reported. Three positive RT-PCR results of test of breast milk have been reported recently. One amniotic fluid testing positive was reported. Conclusion: Possible vertical transmission of SARS CoV-2 has been observed in some studies currently. More RT-PCR tests on amniotic fluid, placenta, breast milk and cord blood are required. Keywords: COVID-19; SARS CoV-2; Vertical transmission; neonatal; pregnancy. |
7/21/2020 | 7/23/2020 | https://www.tandfonline.com/doi/full/10.1080/14767058.2020.1793322 | Multicountry | Review | Deniz M, Tezer H. | J Matern Fetal Neonatal Med | 2020 | Peer-reviewed | 10.1080/14767058.2020.1793322 | English | Yes | Yes | LMIC/HIC | Not applicable | Breast milk/ Breast feeding | Current week | ||||||||||||||||||
| Protecting Breastfeeding during the COVID-19 Pandemic | The severe acute respiratory syndrome–coronavirus-2 (SARS-CoV-2) pandemic has impacted all patient populations including pregnant mothers. There is an incomplete understanding of SARS-CoV-2 pathogenesis and transmission potential at this time and the resultant anxiety has led to variable breastfeeding recommendations for suspected or confirmed mothers with novel coronavirus disease 2019 (COVID-19). Due to the potential concern for transmission of infection from maternal respiratory secretions to the newborn, temporary separation of the maternal-baby dyad, allowing for expressed breast milk to be fed to the infant, was initially recommended but later revised to include breastfeeding by the American Academy of Pediatrics in contrast to international societies, which recommend direct breastfeeding. This separation can have negative health and emotional implications for both mother and baby. Only two publications have reported SARS-CoV-2 in human breast milk but the role of breast milk as a vehicle of transmission of COVID-19 to the newborns still remains unclear and may indeed be providing protective antibodies against SARS-CoV-2 infection even in infected neonates. Other modes of transmission of infection to neonates from infected mothers or any care providers cannot be overemphasized. Symptomatic mothers on hydroxychloroquine can safely breastfeed and no adverse effects were reported in a baby treated with remdesivir in another drug trial. The excretion of sarilumab in human breast milk is unknown at this time. Hence, given the overall safety of breast milk and both short-term and long- term nutritional, immunological, and developmental advantages of breast milk to newborn, breast milk should not be withheld from baby. The setting of maternal care, severity of maternal infection and availability of resources can impact the decision of breastfeeding, the role of shared decision making on breastfeeding between mother and physician needs to be emphasized. We strongly recommend direct breastfeeding with appropriate hygiene precautions unless the maternal or neonatal health condition warrants separation of this dyad. | 7/21/2020 | 7/22/2020 | https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0040-1714277#N68896 | Not applicable | Editorial/commentary/guidance | Cheema R, Partridge E, Kair LR, Kuhn-Riordon KM, Silva AI, Bettinelli ME, Chantry CJ, Underwood MA, Lakshminrusimha S, Blumberg D. | Am J Perinatol | 2020 | Peer-reviewed | 10.1055/s-0040-1714277 | English | Yes | Yes | LMIC/HIC | Not applicable | Breast milk/ Breast feeding | Current week | ||||||||||||||||||
| ADRS due to COVID-19 in midterm pregnancy: successful management with plasma transfusion and corticosteroids | Background: Management of acute respiratory distress syndrome (ARDS) in pregnant women infected with new severe acute respiratory syndrome Corona virus 2 (SARS-CoV2) is a challenging clinical task. Case: A 30- year-old woman (gravid 3, parity 2) presented at her 21 and 2/7 weeks gestation (pre pregnancy BMI: 36.1 kg/m2), with ARDS caused by SARS-CoV2 infection. She received lopinavir/ritonavir and azithromycin as well as early methyl prednisolone therapy. Given the persistent hypoxemia despite oxygen therapy via non rebreather face mask (FiO2:80%), convalescent plasma transfusion was administered that led to a mild clinical improvement as well as decrease in inflammatory markers. Growth of her fetus assessed by obstetric sonography was normal during hospital stay. Conclusion: Judicious corticosteroid therapy along with convalescent plasma transfusion to suppress viremia and cytokine storm can lead to favorable outcome in the pregnant women with ARDS caused by SARS-CoV2 infection without superimposed bacterial infection. Keywords: Pregnancy; SARS-CoV2; acute respiratory distress syndrome; convalescent plasma transfusion; corticosteroid. |
7/26/2020 | 7/28/2020 | https://www.tandfonline.com/doi/full/10.1080/14767058.2020.1797669 | Iran | Descriptive study | Soleimani Z, Soleimani A. | J Matern Fetal Neonatal Med | 2020 | Peer-reviewed | 10.1080/14767058.2020.1797669 | English | Yes | LMIC | 1 pregnant woman | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Covid-19 in pregnant women and babies: What pediatricians need to know | Beginning in late 2019, a novel coronavirus labeled SARS-CoV-2 spread around the world, affecting millions. The impact of the disease on patients and on health care delivery has been unprecedented. Here, we review what is currently known about the effects of the virus and its clinical condition, Covid-19 in areas of relevance to those providing care to neonates. While aspects of pregnancy, including higher expression of the cell receptor for the virus, ACE2, could put these women at higher risk, preliminary epidemiological information does not support this. Viral carriage prevalence based on universal screening show that rates vary from 13% in "hot spots" such as New York City, to 3% in areas with lower cases. Vertical transmission risks are unknown but 3.1% of 311 babies born to mothers with Covid-19 were positive within a week of birth. The clinical description of 26 neonates <30 days of age showed no deaths and only one requiring intensive care. Risks for breast-feeding and for milk banks are discussed | 6/13/2020 | 7/26/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293440/ | Multicountry | Review | Rozycki HJ, Kotecha S. | Paediatr Respir Rev | 2020 | Peer-reviewed | 10.1016/j.prrv.2020.06.006 | English | Yes | Yes | LMIC/HIC | Not applicable | Breast milk/ Breast feeding | Current week | ||||||||||||||||||
| Mild Cytokine Elevation, Moderate CD4(+)‚ÄâT Cell Response and Abundant Antibody Production in Children with COVID-19 | Children with Coronavirus Disease 2019 (COVID-19) were reported to show milder symptoms and better prognosis than their adult counterparts, but the difference of immune response against SARS-CoV-2 between children and adults hasn’t been reported. Therefore we initiated this study to figure out the features of immune response in children with COVID-19. Sera and whole blood cells from 19 children with COVID-19 during different phases after disease onset were collected. The cytokine concentrations, SARS-CoV-2 S-RBD or N-specific antibodies and T cell immune responses were detected respectively. In children with COVID-19, only 3 of 12 cytokines were increased in acute sera, including interferon (IFN)-γ-induced protein 10 (IP10), interleukin (IL)-10 and IL-16. We observed an increase in T helper (Th)-2 cells and a suppression in regulatory T cells (Treg) in patients during acute phase, but no significant response was found in the IFN-γ-producing or tumor necrosis factor (TNF)-α-producing CD8+ T cells in patients. S-RBD and N IgM showed an early induction, while S-RBD and N IgG were prominently induced later in convalescent phase. Potent S-RBD IgA response was observed but N IgA seemed to be inconspicuous. Children with COVID-19 displayed an immunophenotype that is less inflammatory than adults, including unremarkable cytokine elevation, moderate CD4+ T cell response and inactive CD8+ T cell response, but their humoral immunity against SARS-CoV-2 were as strong as adults. Our finding presented immunological characteristics of children with COVID-19 and might give some clues as to why children develop less severe disease than adults. Keywords: COVID-19, SARS-CoV-2, Cytokine, T cell immune response, Antibody dynamics |
7/22/2020 | 7/24/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373847/ | China | Case-control study | Jia R, Wang X, Liu P, Liang X, Ge Y, Tian H, Chang H, Zhou H, Zeng M, Xu J. | Virol Sin | 2020 | Peer-reviewed | 10.1007/s12250-020-00265-8 | English | Yes | LMIC | 19 children with COVID-19 (ages 7 months to 13 years) and 18 age- and gender-matched healthy controls | Yes | Yes | Current week | ||||||||||||||||||
| COVID-19 in pregnant women: A systematic review and meta-analysis | Objective: Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several reports highlighted the risk of infection and disease in pregnant women and neonates. To assess the risk of clinical complications in pregnant women and neonates infected with SARS-CoV-2 carrying out a systematic review and meta-analysis of observational studies. Data sources: Search of the scientific evidence was performed using the engines PubMed and Scopus, including articles published from December 2019 to 15 April 2020. Study eligibility criteria: Only observational studies focused on the assessment of clinical outcomes associated with pregnancy in COVID-19 women were selected. Study appraisal and synthesis methods: The first screening was based on the assessment of titles and abstracts, followed by the evaluation of full-texts. Qualitative variables were summarized with frequencies, whereas quantitative variables with central and variability indicators depending on their parametric distribution. Forest plots were used to describe point estimates and in-between studies variability. Study quality assessment was performed. Results: Thirteen studies were selected. All of them were carried out in China. The mean (SD) age and gestational age of pregnant women were 30.3 (1.5) years and 35.9 (2.9) weeks, respectively. The mean (SD) duration from the first symptoms to the hospital admission and to labour were 5.5 (2.0) and 9.5 (8.7) days, respectively. Patients mainly complained of fever and cough (pooled (95 % CI) proportions were 76.0 % (57.0 %-90.0 %) and 38.0 (28.0 %-47.0 %), respectively). Several antibiotics, antivirals, and corticosteroids were prescribed in different combinations. The pooled prevalence of maternal complications and of caesarean section were 45.0 % (95 % CI: 24.0 %-67.0 %) and 88.0 % (95 %CI: 82.0 %-94.0 %). A proportion of pregnant women less than 20 % were admitted to ICU. The pooled proportion of preterm infants was 23.0 % (95 %CI: 11.0 %-39.0 %). The most frequent neonatal complications were pneumonia and respiratory distress syndrome. The pooled percentage of infected neonates was 6.0 % (95 %CI: 2.0 %-12.0 %). Conclusions: The present study suggests a high rate of maternal and neonatal complications in infected individuals. However, the current scientific evidence highlights a low risk of neonatal infection. Multicentre, cohort studies are needed to better elucidate the role of SARS-CoV-2 during pregnancy. Keywords: COVID-19; Neonate; Pregnancy; SARS-CoV-2; Vertical transmission. |
7/16/2020 | 7/28/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32713730/ | China | Meta-analysis | Capobianco G, Saderi L, Aliberti S, Mondoni M, Piana A, Dessole F, Dessole M, Cherchi PL, Dessole S, Sotgiu G. | Eur J Obstet Gynecol Reprod Biol | 2020 | Peer-reviewed | 10.1016/j.ejogrb.2020.07.006 | English | Yes | Yes | LMIC | 13 studies | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| COVID-19 and Hydatidiform Mole | The emergence of coronavirus disease‐2019 (COVID‐19) as a pandemic threatens the entire world resulting in severe consequences for people's health. Pregnant patients with COVID‐19 had immune dysregulation that could result in abnormal pregnancy outcomes such as hydatidiform mole (HM), recurrent pregnancy loss, and early‐onset preeclampsia. In this article, we tried to summarize the possible association between COVID‐19 and the HM's development by reviewing the role of NOD‐Like Receptor (NLR) Family Pyrin Domain Containing 7 (NLRP7), cytokines, zinc and leucocytes in the pathogenesis of HM. The emergence of coronavirus disease‐2019 (COVID‐19) as a pandemic threatens the entire world resulting in severe consequences for people's health. Pregnant patients with COVID‐19 had immune dysregulation that could result in abnormal pregnancy outcomes such as hydatidiform mole (HM), recurrent pregnancy loss, and early‐onset preeclampsia. In this article, we tried to summarize the possible association between COVID‐19 and the HM's development by reviewing the role of NOD‐Like Receptor (NLR) Family Pyrin Domain Containing 7 (NLRP7), cytokines, zinc and leucocytes in the pathogenesis of HM. The emergence of coronavirus disease-2019 (COVID-19) as a pandemic threatens the entire world resulting in severe consequences for people's health. Pregnant patients with COVID-19 had immune dysregulation that could result in abnormal pregnancy outcomes such as hydatidiform mole (HM), recurrent pregnancy loss, and early-onset preeclampsia. In this article, we tried to summarize the possible association between COVID-19 and the HM's development by reviewing the role of NOD-Like Receptor (NLR) Family Pyrin Domain Containing 7 (NLRP7), cytokines, zinc and leucocytes in the pathogenesis of HM. Keywords: COVID-19; Gestational trophoblastic diseases; Hydatidiform mole; coronavirus. |
7/22/2020 | 7/23/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.13310 | Not applicable | Review | Abbas AM, Ahmed L, Salem AS, Elsamman SH, Refai A, Fathy SK, Ahmed OA, Shalotut AS, AbdelWahab RA. | Am J Reprod Immunol | 2020 | Peer-reviewed | 10.1111/aji.13310 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Influence of Race and Ethnicity on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Rates and Clinical Outcomes in Pregnancy | None available | 7/21/2020 | 7/24/2020 | https://journals.lww.com/greenjournal/Citation/9000/Influence_of_Race_and_Ethnicity_on_Severe_Acute.97290.aspx | USA | Cross-sectional study | Emeruwa UN, Spiegelman J, Ona S, Kahe K, Miller RS, Fuchs KM, Aubey JJ, Booker W, D ºAlton ME, Friedman AM, Aziz A, Sutton D, Purisch SE, Goffman D, Melamed A, Gyamfi-Bannerman C. | Obstet Gynecol | 2020 | Peer-reviewed | 10.1097/AOG.0000000000004088 | English | Yes | HIC | 673 pregnant women, including 100 women who tested positive for SARS-CoV-2 | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Impact of the COVID-19 Pandemic on Partner relationships, Sexual and Reproductive Health: A Cross-sectional Online Survey | Background: In the past few months, the coronavirus disease COVID-19 pandemic has caused extensive economic and social damage. Objective: The purpose of this study was to assess the impact of COVID-19 pandemic and related containment measures on partner relationships, sexual and reproductive health. Methods: From May 1 to 5, 2020, we recruited 3,500 young Chinese online. Aspects of sexual and reproductive health obtained using a study-specific questionnaire. Results: 967 participants were included the sexual health analysis. Due to the COVID-19 pandemic and related containment measures, 212 out of 967 participants (22%) reported a decrease in sexual desire; 41% (n=396) participants experienced a decrease in the sexual frequency; 30% (n=291) participants reported an increase in the frequency of masturbation; 20% (n=192) participants reported a decrease in consumed alcohol before or during sexual activities and 31% (n=298) participants reported a deterioration of partner relationship during the pandemic. The logistic regression analysis indicated that accommodation during pandemic (P = .046; OR=0.59; 95 %CI = 0.30~0.86), in/not in an exclusive relationship (P <.001; OR=0.44; 95 %CI = 0.27~0.73), sexual desire (P = .016; OR=2.01; 95 %CI = 1.38~2.97) and sexual satisfaction (P <.001; OR=1.92; 95 %CI = 1.54~2.50) were closely related to partner relationships. COVID-19 also caused disruption in reproductive health services such as prenatal and postnatal care, safe childbirth, safe abortion, contraception and the management of sexually transmitted infections. Conclusions: Our results show that due to COVID-19 pandemic and related containment measures, many young participants have wide ranging issues affecting their sexual and reproductive health. Measures should be put in place to safeguard the sexual and reproductive health of young people during this pandemic. |
7/22/2020 | 7/28/2020 | https://preprints.jmir.org/preprint/20961/accepted | China | Cross-sectional study | Li G, Tang D, Song B, Wang C, Shen Q, Xu C, Geng H, Wu H, He X, Cao Y. | J Med Internet Res | 2020 | Peer-reviewed | 10.2196/20961 | English | Yes | Yes | LMIC | 967 participants in overall analysis, 25 participants with responses about maternal care and delivery services | Yes | Current week | ||||||||||||||||||
| The downstream effects of COVID-19: a call for supporting family wellbeing in the NICU | Parents of NICU infants are a vulnerable population from a psychological perspective, and often experience high levels of acute stress, depression, anxiety, and post-traumatic stress. The added burden of the current SARS CoV-2 disease (COVID-19) pandemic is likely to exacerbate these issues, with potential implications for the wellbeing of infants and families in the short- and long-term. In this paper, we propose utilizing the stress contagion framework and consider how psychosocial stress can "spill over" into the parent-infant relationship domain, which can impact child development and family wellbeing longer term. As the effects of the pandemic will likely persist well beyond the acute stage, we offer advocacy points and general guidelines for healthcare professionals to consider in their quest to mitigate stress and build resilience in NICU families. | 7/24/2020 | 7/26/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378407/ | Not applicable | Editorial/commentary/guidance | Erdei C, Liu CH. | J Perinatol | 2020 | Peer-reviewed | 10.1038/s41372-020-0745-7 | English | Yes | Yes | LMIC/HIC | Not applicable | Mental health | Current week | ||||||||||||||||||
| Review of guidelines and recommendations from 17 countries highlights the challenges that clinicians face caring for neonates born to mothers with COVID-19 | Aim: This review examined how applicable national and regional clinical practice guidelines and recommendations for managing neonates born to mothers with COVID-19 mothers were to the evolving pandemic. Methods: A systematic search and review identified 20 guidelines and recommendations that had been published by 25 May 2020. We analysed documents from 17 countries: Australia, Brazil, Canada, China, France, India, Italy, Japan, Saudi Arabia, Singapore, South Africa, South Korea, Spain, Sweden, Switzerland, the UK and the USA. Results: The documents were based on expert consensus with limited evidence and were of variable, low methodological rigour. Most did not provide recommendations for delivery methods or managing symptomatic infants. None provided recommendations for post-discharge assimilation of potentially-infected infants into the community. The majority encouraged keeping mothers and infants together, subject to infection control measures, but one-third recommended separation. Although breastfeeding or using breastmilk were widely encouraged, two countries specifically prohibited this. Conclusion: The guidelines and recommendations for managing infants affected by COVID-19 were of low, variable quality and may be unsustainable. It is important that transmission risks are not increased when new information is incorporated into clinical recommendations. Practice guidelines should emphasise the extent of uncertainty and clearly define gaps in the evidence. Keywords: COVID-19; neonate; perinatal care; practice guidelines; transmission. |
7/27/2020 | 7/28/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.15495 | Multicountry | Review | Yeo KT, Oei JL, De Luca D, Schmölzer GM, Guaran R, Palasanthiran P, Kumar K, Buonocore G, Cheong J, Owen LS, Kusuda S, James J, Lim G, Sharma A, Uthaya S, Gale C, Whittaker E, Battersby C, Modi N, Norman M, Naver L, Giannoni E, Diambomba Y, Shah PS, Gagliardi L, Harrison M, Pillay S, Alburaey A, Yuan Y, Zhang H. | Acta Paediatr | 2020 | Peer-reviewed | 10.1111/apa.15495 | English | Yes | LMIC/HIC | Not applicable | Breast milk/ Breast feeding | Current week | |||||||||||||||||||
| Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain | Some clusters of children with a multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C) have been reported. We describe the epidemiological and clinical features of children with MIS-C in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection. Keywords: COVID-19; Kawasaki disease; Multisystem inflammatory syndrome; Pediatric inflammatory multisystemic syndrome; SARS-CoV-2. |
7/25/2020 | 7/26/2020 | https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa1042/5876334 | Spain | Descriptive study | Moraleda C, Serna-Pascual M, Soriano-Arandes A, Simó S, Epalza C, Santos M, Grasa C, Rodríguez M, Soto B, Gallego N, Ruiz Y, Urretavizcaya-Martínez M, Pareja M, Sanz-Santaeufemia FJ, Fumadó V, Lanaspa M, Jordan I, Prieto L, Belda S, Toral-Vázquez B, Rincón E, Gil-Villanueva N, Méndez-Echevarría A, Castillo-Serrano A, Rivière JG, Soler-Palacín P, Rojo P, Tagarro A. | Clin Infect Dis | 2020 | Peer-reviewed | 10.1093/cid/ciaa1042 | English | Yes | HIC | 31 children (median age: 7.6 years, IQR: 4.5 - 11.5 years) | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| COVID-19 and pregnancy: an opportunity to correct an historic gender bias | Current literature and clinical guidelines do not include pregnant women as an a priori risk group for COVID‐19. However, a gender vision of health begs the question: Why are pregnant women not considered a risk group for COVID‐19? The answer is clear: historically, most community scientific studies have not considered female gender, or pregnancy as a state, to be a focus of special interest or effort. Unfortunately, this bias seems to be maintained in COVID‐19 epidemic: most current guidelines for diagnosing SARS‐CoV‐2 infection during pregnancy apply the same standard criteria as for the general population. | 7/24/2020 | 7/25/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.26350 | Not applicable | Editorial/commentary/guidance | Comas C, Carreras E. | J Med Virol | 2020 | Peer-reviewed | 10.1002/jmv.26350 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Multisystem Inflammatory Syndrome in Children: Is There a Linkage to Kawasaki Disease? | Since 1967, researches have hunted for an etiology for Kawasaki Disease (KD). Meanwhile, the 2019 Coronavirus Disease (COVID-19) pandemic has produced a strange new illness termed multisystem inflammatory syndrome in children (MIS-C) and raised hopes that a cause for KD may be identified. This current review paper discusses KD and its potential connection to pediatric COVID-19 and MIS-C illness. Keywords: COVID-19, Pediatric multisystem inflammatory syndrome (PMIS), Multisystem inflammatory syndrome in children (MIS-C), Kawasaki disease, Pediatric cardiology |
7/20/2020 | 7/24/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370900/ | Not applicable | Review | Loke YH, Berul CI, Harahsheh AS. | Trends Cardiovasc Med | 2020 | Peer-reviewed | 10.1016/j.tcm.2020.07.004 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| COVID-19 and the need for child and adolescent telepsychiatry services, a case report | None available | 7/16/2020 | 7/25/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365103/ | India | Editorial/commentary/guidance | Patra S, Patro BK. | Asian J Psychiatr | 2020 | Peer-reviewed | 10.1016/j.ajp.2020.102298 | English | Yes | LMIC | Not applicable | Mental health | Current week | |||||||||||||||||||
| Diagnosing SARS-CoV-2 Related Multisystem Inflammatory Syndrome in Children (MIS-C): Focus on the Gastrointestinal Tract and the Myocardium | None available | 7/27/2020 | 7/28/2020 | https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa1080/5876871 | Not applicable | Editorial/commentary/guidance | Rowley AH. | Clin Infect Dis | 2020 | Peer-reviewed | 10.1093/cid/ciaa1080 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Well-being of Parents and Children During the COVID-19 Pandemic: A National Survey | Background: As the COVID-19 pandemic spread across the US and protective measures to mitigate its impact were enacted, parents and children experienced widespread disruptions in daily life. The objective of this national survey was to determine how the pandemic and mitigation efforts affected the physical and emotional wellbeing of parents and children in the US through early June 2020. Methods: In June 2020, we conducted a national survey of parents with children under age 18 to measure changes in health status, insurance status, food security, utilization of public food assistance resources, childcare and use of health care services since the pandemic began. Results: Since March 2020, 27% of parents reported worsening mental health for themselves, and 14% reported worsening behavioral health for their children. The proportion of families with moderate or severe food insecurity increased from 6% before March 2020 to 8% after, employer sponsored insurance coverage of children decreased from 63% to 60%, and 24% of parents reported a loss of regular childcare. Worsening mental health for parents occurred alongside worsening behavioral health for children in nearly 1 in 10 families, among whom 48% reported loss of regular childcare, 16% reported change in insurance status, and 11% reported worsening food security. Conclusions: The COVID-19 pandemic has had a substantial tandem impact on parents and children in the US. As policymakers consider additional measures to mitigate the health and economic effects of the pandemic, they should consider the unique needs of families with children. |
7/24/2020 | 7/26/2020 | https://pediatrics.aappublications.org/content/early/2020/07/22/peds.2020-016824.long | USA | Cross-sectional study | Patrick SW, Henkhaus LE, Zickafoose JS, Lovell K, Halvorson A, Loch S, Letterie M, Davis MM. | Pediatrics | 2020 | Peer-reviewed | 10.1542/peds.2020-016824 | English | Yes | Yes | HIC | 1,011 responses, survey weights were subsequently applied | Yes | Mental health | Current week | |||||||||||||||||
| Providing women's health care during COVID-19: Personal and professional challenges faced by health workers | None available | 7/21/2020 | 7/22/2020 | https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.13313 | Multicountry | Review | Green L, Fateen D, Gupta D, McHale T, Nelson T, Mishori R. | Int J Gynaecol Obstet | 2020 | Peer-reviewed | 10.1002/ijgo.13313 | English | Yes | Yes | LMIC/HIC | Not applicable | Current week | |||||||||||||||||||
| Complicated Appendicitis in a Pediatric Patient With COVID-19: A Case Report | Perforated appendicitis is a well-known complication of acute appendicitis (AA), which increases the morbidity rate in children. This report discusses the case of a pediatric patient with perforated appendicitis with a secondary diagnosis of coronavirus disease 2019 (COVID-19). The clinical presentation of complicated appendicitis (CA) in association with COVID-19 may not be different from that in the general population. Our patient underwent successful management with open appendectomy and subsequent antibiotics. There is no evidence to alter the standard of care for such patients. So further studies are needed to provide more clarity on the appropriate management. Keywords: appendicitis, covid-19, pediatric |
6/17/2020 | 7/24/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370680/ | Saudi Arabia | Descriptive study | Alsuwailem AB, Turkistani R, Alomari M. | Cureus | 2020 | Peer-reviewed | 10.7759/cureus.8677 | English | Yes | HIC | 14-year-old child | Yes | Yes | Current week | ||||||||||||||||||
| Management of mother-newborn dyads in the COVID-19 era | None available | 7/23/2020 | 7/27/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377774/ | Not applicable | Editorial/commentary/guidance | Medvedev MM. | Lancet Child Adolesc Health | 2020 | Peer-reviewed | 10.1016/S2352-4642(20)30241-8 | English | Yes | Yes | Yes | LMIC/HIC | Not applicable | Breast milk/ Breast feeding | Current week | |||||||||||||||||
| Trends in Pediatric Emergency Department Utilization after Institution of COVID-19 Mandatory Social Distancing | None available | 7/20/2020 | 7/24/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370904/ | USA | Quasi-experimental study | Chaiyachati BH, Agawu A, Zorc JJ, Balamuth F. | J Pediatr | 2020 | Peer-reviewed | 10.1016/j.jpeds.2020.07.048 | English | Yes | Yes | HIC | 4 16 week periods (2017-2020) | Yes | Current week | ||||||||||||||||||
| COVID-19 Virus in a 6-Day-Old Girl Neonate: A Case Report | None available | 7/22/2020 | 7/24/2020 | https://journals.sagepub.com/doi/10.1177/0009922820946010?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed | Iran | Descriptive study | Eghbalian F, Esfahani AM, Jenabi E. | Clin Pediatr (Phila) | 2020 | Peer-reviewed | 10.1177/0009922820946010 | English | Yes | LMIC | 1 neonate | Yes | Yes | Yes | Current week | |||||||||||||||||
| The potential benefits of Chinese integrative medicine for pregnancy women during the COVID-19 pandemic | None available | 6/24/2020 | 7/25/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311349/ | Not applicable | Editorial/commentary/guidance | Wang W, Zhang Q, Qu F. | Integr Med Res | 2020 | Peer-reviewed | 10.1016/j.imr.2020.100461 | English | Yes | LMIC/HIC | Not applicable | Mental health | Current week | |||||||||||||||||||
| Infectious Diseases Diagnoses of Children Admitted With Symptoms of Coronavirus Disease 2019 During an Outbreak in New York City | None available | 7/27/2020 | 7/28/2020 | https://journals.sagepub.com/doi/10.1177/0009922820944399?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed | USA | Descriptive study | Acker KP, Schertz K, Abramson EL, DeLaMora P, Salvatore CM, Han JY. | Clin Pediatr (Phila) | 2020 | Peer-reviewed | 10.1177/0009922820944399 | English | Yes | Yes | HIC | 42 children (range 5 days to 17 years and 11 months) | Yes | Yes | Current week | |||||||||||||||||
| Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease | Background Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of an emerging pediatric multi-inflammatory syndrome mimicking Kawasaki disease (KD). Main body This report reveals that coronaviridae were implicated in induction of several post-infectious vasculitides, namely, KD, AHEI, and HSP. This occurs in genetically susceptible individuals to vascular inflammation. Shared genetic susceptibilities between KD and CoV include genes encoding for CD 40, HLAB-15:03, and ACE. This leads to augmented inflammation with hypersecretion of cytokines especially IL-6. Conclusion The revealed relationships between KD and CoV can help to predict the risk of KD in COVID-19 patients through screening levels of upregulated cytokines. It might also signify that classic treatment of KD with IVIG might need to be replaced with anti-cytokine therapy in COVID-19 patients. |
7/1/2020 | 7/23/2020 | https://epag.springeropen.com/articles/10.1186/s43054-020-00029-9 | Not applicable | Review | AbdelMassih A.F., AbdelAzeam A.S., Ayad A., Kamel A.Y., Khalil A., Kotb B., Waheed D., Menshawey E., Sefein F., Taha F., Ismail H.-A., Osman I., Iskander J., El Wakil L., Rashad L., Arsanyous M.B., El Shershaby M., Mansour M., Ashraf M., Hafez N., Abuzeid N.M., AbdElSalam N.M.-N., Hafez N.G., Youssef N., Hozaien R., Saeed R., Kamel D., AbdelHameed M.A., Ali S. | Egyptian Pediatric Association Gazette (2020) 68:1 Article Number: 21. Date of Publication: 1 Dec 2020 | 2020 | Peer-reviewed | 10.1186/s43054-020-00029-9 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| A Review of COVID-19 in Children | Since the outbreak of COVID-19, global concern emerged inspiring scientists to dedicate more attention to this pandemic. The disease caused by a novel coronavirus requires urgent striking action to probe the disease phases and find a proper cure. In this regard, the necessity of brief and thorough explanations comes into view. In this study, we gathered useful information about the virology, pathogenesis, epidemiology, manifestations, diagnosis, and treatment with special consideration of pediatric patients. This review article helps medical caregivers to receive a quick and effective approach to deal with this disease in their practice. | 5/18/2020 | 7/23/2020 | https://sites.kowsarpub.com/jcp/articles/103780.html | Not applicable | Review | Khoshnevisasl P., Sadeghzadeh M., Sadeghzadeh S. | Journal of Comprehensive Pediatrics (2020) 11:3 Article Number: e103780. Date of Publication: 1 Aug 2020 | 2020 | Peer-reviewed | 10.5812/compreped.103780 | English | Yes | Yes | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||
| The necessity of paying more attention to the neurological and psychological problems caused by covid-19 pandemic during pregnancy | None available | 7/17/2020 | 7/24/2020 | http://www.ijwhr.net/pdf/pdf_IJWHR_521.pdf | Not applicable | Editorial/commentary/guidance | Haghdoost S.M., Gol M.K. | International Journal of Women's Health and Reproduction Sciences (2020) 8:3 (243-244). Date of Publication: 1 Jul 2020 | 2020 | Peer-reviewed | 10.15296/ijwhr.2020.40 | English | Yes | LMIC/HIC | Not applicable | Mental health | Current week | |||||||||||||||||||
| Neonatal sars-cov-2 infection and congenital myocarditis: A case report and literature review | Introduction: With the outbreak of coronavirus 2019 (SARS-COV-2), the prevention and control of SARS-COV-2 infection in pregnant women and the potential risk of vertical transmission has become a major concern. Case Presentation: We report the case of a newborn in Iran with the manifestations of myocarditis at birth. The diagnosis of SARS-COV-2 infection was confirmed for the mother and the neonate by real-time reverse transcription polymerase chain reaction (rRT-PCR) using a pharyngeal specimen. Conclusions: Based on our literature review, there is still insufficient evidence to determine the effect of SARS-COV-2 infection on the fetus. Given the possibility of cardiac injury in SARS-COV-2 disease and manifestation of congenital myocarditis in our case, maternal vertical transmission of SARS-COV-2 could be considered. |
6/15/2020 | 7/22/2020 | https://sites.kowsarpub.com/apid/articles/103504.html | Iran | Descriptive study | Amiraskari R., Sayarifard E., Kharrazi H., Naserfar N., Sayarifard A. | Archives of Pediatric Infectious Diseases (2020) 8:3 (1-7) Article Number: e103504. Date of Publication: 1 Jun 2020 | 2020 | Peer-reviewed | 10.5812/pedinfect.103504 | English | Yes | Yes | LMIC | 1 pregnant woman and 1 neonate | Yes | Yes | Yes | Yes | Current week | |||||||||||||||
| COVID-19 pandemic: The concerns of pediatric neurologists | None available | 5/6/2020 | 7/24/2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313594/ | Not applicable | Editorial/commentary/guidance | Saini A., Suthar R. | Annals of Indian Academy of Neurology (2020) 23:3 (358-359). Date of Publication: 1 May 2020 | 2020 | Peer-reviewed | 10.4103/aian.AIAN_407_20 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Complaints and physical examination findings of covid-19 reported in childhood | None available | 7/24/2020 | 7/24/2020 | http://www.jpi-turkey.org/upload/documents/2020-01/2020-14-1-049-050.pdf | Not applicable | Descriptive study | Oygar P.D. | Cocuk Enfeksiyon Dergisi (2020) 14:1 (49-50). Date of Publication: 1 Mar 2020 | 2020 | Peer-reviewed | 10.5578/ced.202018 | Turkish | LMIC/HIC | Not applicable | Current week | |||||||||||||||||||||
| From the trenches: inpatient management of coronavirus disease 2019 in pregnancy | The novel coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 has become a pandemic. It has quickly swept across the globe, leaving many clinicians to care for infected patients with limited information about the disease and best practices for care. Our goal is to share our experiences of caring for pregnant and postpartum women with novel coronavirus disease 2019 in New York, which is the coronavirus disease 2019 epicenter in the United States, and review current guidelines. We offer a guide, focusing on inpatient management, including testing policies, admission criteria, medical management, care for the decompensating patient, and practical tips for inpatient antepartum service management. Key words coronavirus disease in pregnancyCOVID-19 in pregnancycritical care in pregnancycritical care obstetricsinfectious disease in pregnancymanagement of COVID-19 |
6/15/2020 | 7/23/2020 | https://www.sciencedirect.com/science/article/pii/S2589933320300987 | USA | Editorial/commentary/guidance | Vega M., Hughes F., Bernstein P.S., Goffman D., Sheen J.-J., Aubey J.J., Zork N., Nathan L.M. | American Journal of Obstetrics and Gynecology MFM (2020) Article Number: 100154. Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1016/j.ajogmf.2020.100154 | English | Yes | Yes | LMIC/HIC | Not applicable | Breast milk/ Breast feeding | Current week | ||||||||||||||||||
| Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019 | Objective Treatment of coronavirus disease 2019 is mostly symptomatic, but a wide range of medications are under investigation against severe acute respiratory syndrome coronavirus 2. Although pregnant women are excluded from clinical trials, they will inevitably receive therapies whenever they seem effective in nonpregnant patients and even under compassionate use. Methods We conducted a review of the literature on placental transfer and pregnancy safety data of drugs under current investigation for coronavirus disease 2019. Results Regarding remdesivir, there are no data in pregnant women. Several other candidates already have safety data in pregnant women, because they are repurposed drugs already used for their established indications. Thus, they may be used in pregnancy, although their safety in the context of coronavirus disease 2019 may differ from conventional use. These include HIV protease inhibitors such as lopinavir/ritonavir that have low placental transfer, interferon that does not cross the placental barrier, and hydroxychloroquine or chloroquine that has high placental transfer. There are also pregnancy safety and placental transfer data for colchicine, steroids, oseltamivir, azithromycin, and some monoclonal antibodies. However, some drugs are strictly prohibited in pregnancy because of known teratogenicity (thalidomide) or fetal toxicities (renin-angiotensin system blockers). Other candidates including tocilizumab, other interleukin 6 inhibitors, umifenovir, and favipiravir have insufficient data on pregnancy outcomes. Conclusion In life-threatening cases of coronavirus disease 2019, the potential risks of therapy to the fetus may be more than offset by the benefit of curing the mother. Although preclinical and placental transfer studies are required for a number of potential anti-severe acute respiratory syndrome coronavirus 2 drugs, several medications can already be used in pregnant women. Key words coronavirus disease 2019placentapregnancysevere acute respiratory syndrome coronavirus 2 |
6/22/2020 | 7/24/2020 | https://www.sciencedirect.com/science/article/pii/S2589933320301038 | Not applicable | Review | Louchet M., Sibiude J., Peytavin G., Picone O., Tréluyer J.-M., Mandelbrot L. | American Journal of Obstetrics and Gynecology MFM (2020) Article Number: 100159. Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1016/j.ajogmf.2020.100159 | English | Yes | LMIC/HIC | Not applicable | Current week | ||||||||||||||||||||
| Obstetric anaesthesia during the COVID-19 pandemic | Pregnant women and parturients have also been concerned by the COVID-19 pandemic. However, they are not especially at risk for severe forms of the disease prone to induce prematurity but without transmission to the fœtus. Obstetrical management of parturients have changed with an extensive use of teleconsultation and a limitation of relatives in the delivery room and in the ward. The choice of the mode of delivery remains determined by obstetrical reasons, and use of regional anaesthesia remains recommended for labour and caesarean section provided there is not haemostasis disorders. The pandemic issue has not change management of fever and hypertension. The post-partum period is more impacted due to an increased risk of thromboembolic events justifying an extended use of anticoagulants. On the other hand, the use of non-steroidal anti-inflammatory drugs is restricted. The key point was cooperation between obstetricians, anaesthesiologists, intensivists and pediatrician. | 7/10/2020 | 7/27/2020 | https://www.sciencedirect.com/science/article/pii/S1279796020300929 | Not applicable | Review | Ung N., Bonnet M.P. | Praticien en Anesthesie Reanimation (2020). Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1016/j.pratan.2020.07.005 | French | Yes | Yes | LMIC/HIC | Not applicable | Current week | |||||||||||||||||||
| High prevalence of SARS-CoV-2 and influenza A virus (H1N1) co-infection in dead patients in Northeastern Iran | In the last months of 2019, an outbreak of fatal respiratory disease started in Wuhan, China, and quickly spread to other parts of the world. It named COVID‐19, and to date, thousands of cases of infection and death reported worldwide. The disease is associated with a wide range of symptoms that make it difficult to diagnose it accurately. The previous SARS pandemic in 2003, researchers found that the patients with fever, cough, or sore throat had a 5% influenza virus‐positive rate. This finding sparked in our minds that the wide range of symptoms and also relatively high prevalence of death in our patients may be due to the co‐infection with other viruses. Thus, we evaluate the co‐infection of SARS‐CoV‐2 with other respiratory viruses in dead patients in North Khorasan. We evaluated the presence of influenza A/B virus, Human metapneumovirus, bocavirus, adenovirus, respiratory syncytial virus, and parainfluenza viruses in 105 SARS‐CoV‐2 positive dead patients, using PCR and RT‐PCR tests. We found co‐infection with influenza virus in 22.3%, respiratory syncytial virus, and bocavirus in 9.7%, parainfluenza viruses in 3.9%, Human metapneumovirus in 2.9% and finally adenovirus in 1.9% of SARS‐CoV‐2 positive dead cases. The highlights of our findings are a high prevalence of co‐infection with influenza A virus and the monopoly of co‐infection with Human metapneumovirus in children. |
7/28/2020 | 7/29/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.26364 | Iran | Cross-sectional study | Hashemi SA, Safamanesh S, Zadeh-Moghaddam HG, Ghafouri M, Amir A. | J Med Virol | 2020 | Peer-reviewed | 10.1002/jmv.26364 | English | Yes | LMIC | 105 | Yes | Yes | Yes | Current week | |||||||||||||||||
| Assisted reproduction and Coronavirus in Italy | OBJECTIVE: A novel type of Coronavirus was identified in China in December 2019. The first cases of a form of pneumonia of unknown etiology were detected at the beginning of that month in Wuhan. The virus is believed to have emerged at the Wuhan Huanan Seafood Market, where transmission of a zoonotic pathogen to humans occurred. PATIENTS AND METHODS: Some studies conducted in China during the epidemic report small numbers of pregnant women infected with SARS-CoV-2 and some pregnancy complications in patients with COVID-19. However, they fail to document the transplacental passage of the virus from mother to fetus. RESULTS: Following the COVID-19 outbreak, guidelines for couples who are undergoing treatments of assisted reproduction have been issued by the International Federation for Fertility Societies (IFFS), the American Society for Reproductive Medicine (ASRM), the European Society of Human Reproduction and Embryology (ESHRE) and the Latin American Network of Assisted Reproduction (REDLARA). They recommend couples to discuss assisted reproduction with their doctors while those at risk or with SARS-CoV-2 should consider freezing oocytes or embryos and retransferring them later. CONCLUSIONS: Other than the US, Italy is the country with the highest number of cases (197675 positives, 26644 deaths) (updated on April 26). The Italian National Transplant Centre and the Higher Institute of Health advised on March 17 to complete the cycles already started and not to start new cycles. Phase 2 will begin on 4 May with an increase in freedom of action and fertilization treatments will start again. The Society that brings together embryologists (SIERR) has issued the guidelines to be followed when this happens. |
7/21/2020 | 7/25/2020 | https://www.europeanreview.org/article/21924 | Italy | Editorial/commentary/guidance | Pasquale C, Montanino Oliva M, Benedetti M, Berlinghieri V, Bielli W, Buonomo G, Carfagna P, Costantino A, Cristofano D, Iacomino D, Lippa A, Lisi R, Ortensi I, Quinzi A, Giorlandino C, Lisi F. | Eur Rev Med Pharmacol Sci | 2020 | Peer-reviewed | 10.26355/eurrev_202007_21924 | English | Yes | Yes | HIC | Not applicable | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| A multicentre observational study on neonates exposed to SARS-CoV-2 in China: the Neo-SARS-CoV-2 Study protocol | Introduction An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan, China starting in December 2019. Yet the clinical features and long-term outcomes of neonates with SARS-CoV-2 exposure are lacking. The purpose of this study is to describe the clinical course and prognosis of the neonates exposed to SARS-CoV-2. Methods and analysis This is a multicentre observational study conducted at the designated children and maternal and child hospitals in the mainland of China. Neonates exposed to SARS-CoV-2 infection will be recruited. The data to be collected via case report forms include demographic details, clinical features, laboratory and imaging results, as well as outcomes. Primary outcomes are the mortality of neonates with COVID-19 and SARS-CoV-2 infection of neonates born to mothers with COVID-19. Secondary outcomes are the birth weight, premature delivery and neurological development of neonates exposed to SARS-CoV-2. The neurological development is assessed by the Chinese standardised Denver Developmental Screening Test at the corrected age of 6 months. Ethics and dissemination This study has been approved by the Children's Hospital of Fudan University ethics committee (No. (2020)31). The study findings will be disseminated in peer-reviewed journals and presented at national and international conferences in order to improve the understanding of the clinical course among neonates exposed to SARS-CoV-2 and to provide evidence-based treatment and prevention strategies for this group. |
7/22/2020 | 7/24/2020 | https://bmjopen.bmj.com/content/10/7/e038004 | China | Protocol/study design | Xiao T, Xia S, Zeng L, Lin G, Wei Q, Zhou W, Zhuang D, Chen X, Yi B, Li L, Mi H, Yin Z, Cheng X, Wang L, Hu X, Zhou W. | BMJ Open | 2020 | Peer-reviewed | 10.1136/bmjopen-2020-038004 | English | Yes | LMIC | Not applicable | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Mistakes from the HIV pandemic should inform the COVID-19 response for maternal and newborn care | Background In an effort to prevent infants being infected with SARS-CoV-2, some governments, professional organisations, and health facilities are instituting policies that isolate newborns from their mothers and otherwise prevent or impede breastfeeding. Weighing of risks is necessary in policy development Such policies are risky as was shown in the early response to the HIV pandemic where efforts to prevent mother to child transmission by replacing breastfeeding with infant formula feeding ultimately resulted in more infant deaths. In the COVID-19 pandemic, the risk of maternal SARS-CoV-2 transmission needs to be weighed against the protection skin-to-skin contact, maternal proximity, and breastfeeding affords infants. Conclusion Policy makers and practitioners need to learn from the mistakes of the HIV pandemic and not undermine breastfeeding in the COVID-19 pandemic. It is clear that in order to maximise infant health and wellbeing, COVID-19 policies should support skin-to-skin contact, maternal proximity, and breastfeeding. |
7/25/2020 | 7/27/2020 | https://internationalbreastfeedingjournal.biomedcentral.com/articles/10.1186/s13006-020-00306-8 | Multicountry | Editorial/commentary/guidance | Gribble K, Mathisen R, Ververs MT, Coutsoudis A. | Int Breastfeed J | 2020 | Peer-reviewed | 10.1186/s13006-020-00306-8 | English | Yes | Yes | LMIC/HIC | Not applicable | Yes | Yes | Yes | Yes | Breast milk/ Breast feeding | Current week | ||||||||||||||
| Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China | Rationale: The outbreak of coronavirus disease 2019 (COVID-19) in 2019 has become a global pandemic. It is not known whether the disease is associated with a higher risk of infection in pregnant women or whether intrauterine vertical transmission can occur. We report 2 cases of pregnant women diagnosed with COVID-19. Patient concerns: In all of Yichang city from January 20, 2020, to April 9, 2020, only 2 pregnant women, who were in the late stage of pregnancy, were diagnosed with COVID-19; one patient was admitted for fever with limb asthenia, and the other patient was admitted for abnormal chest computed tomography results. Diagnoses: Both pregnant women were diagnosed with COVID-19. Interventions: After the medical staff prepared for isolation and protection, the 2 pregnant women quickly underwent cesarean sections. A series of tests, such as laboratory, imaging, and SARS-CoV-2 nucleic acid examinations, were performed on the 2 women with COVID-19 and their newborns. Outcomes: One of the 2 infected pregnant women had severe COVID-19, and the other had mild disease. Both babies were delivered by cesarean section. Both of the women with COVID-19 worsened 3 to 6 days after delivery. Chest computed tomography suggested that the lesions due to SARS-CoV-2 infection increased. These women began to exhibit fever or reduced blood oxygen saturation again. One of the 2 newborns was born prematurely, and the other was born at full term. Neither infant was infected with COVID-19, but both had increased prothrombin time and fibrinogen, lactate dehydrogenase, phosphocreatine kinase, and creatine kinase isoenzyme contents. Lessons: SARS-CoV-2 infection was not found in the newborns born to the 2 pregnant women with COVID-19, but transient coagulation dysfunction and myocardial damage occurred in the 2 newborns. Effective management strategies for pregnant women with COVID-19 will help to control the outbreak of COVID-19 among pregnant women. |
7/17/2020 | 7/25/2020 | https://journals.lww.com/md-journal/FullText/2020/07170/Coronavirus_disease_2019__COVID_19__in_pregnancy_.126.aspx | China | Descriptive study | Zheng T, Guo J, He W, Wang H, Yu H, Ye H. | Medicine (Baltimore) | 2020 | Peer-reviewed | 10.1097/MD.0000000000021334 | English | Yes | Yes | LMIC | 2 | Yes | Yes | Yes | Yes | Yes | Yes | Current week | |||||||||||||
| Clinical Characteristics of Children With COVID-19: A Meta-Analysis | Background: With the global spread of novel coronavirus disease 2019 (COVID-19), health care systems are facing formidable challenges. Scientists are conducting studies to explore this new disease, and numerous studies have been shared. However, the number of studies on children with COVID-19 is limited, and no meta-analysis of this group has been performed. Methods: A random-effect meta-analysis was conducted to determine the characteristics of children with COVID-19, including their demographic, epidemiological, clinical, laboratory, imaging features, and outcomes. Four databases and reference lists were screened. Percentages were calculated, and pooled prevalence with 95% confidence intervals (CIs) were reported. Results: Of 195 studies, 33 were selected, and 14 (371 patients) of them were included in the meta-analysis. Then, 19 case reports (25 patients) were summarized separately. Our meta-analysis revealed that 17.4% (95% CI = 9.1–27.3) of children had asymptomatic infection. Fever (51.2%, 95% CI = 40.2–62.2) and cough (37.0%, 95% CI = 25.9–48.8) were the most frequent symptoms. The prevalence of severe or critical illness was almost 0% (95% CI = 0–1.0). The most frequent abnormal laboratory findings, in pediatric patients, were leukopenia/lymphopenia (28.9%, 95% CI = 19.5–39.2) and increased creatine kinase (20.1%, 95% CI = 1.3–49.9). Ground-glass opacity was observed in the CT scan of 53.9% (95% CI = 38.4–68.7) of children diagnosed with pneumonia. Conclusions: Children are at a lower risk of developing COVID-19 and have a milder disease than adults. However, the evidence presented in this study is not satisfactory. Further investigations are urgently needed, and our data will be continuously updated. |
7/3/2020 | 7/29/2020 | https://www.frontiersin.org/articles/10.3389/fped.2020.00431/full | Multicountry | Meta-analysis | Ding Y, Yan H, Guo W. | Front Pediatr | 2020 | Peer-reviewed | 10.3389/fped.2020.00431 | English | Yes | Yes | LMIC/HIC | 14 studies (n=371); 19 case reports (n=25) | Yes | Yes | Yes | Yes | Current week | |||||||||||||||
| Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series | Objective To investigate the maternal and infant outcomes of full-term pregnant patients in Wuhan, China, who were infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for coronavirus disease 2019 (COVID-2019). Design Retrospective case series. Setting The Central Hospitals of Wuhan, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China. Participants Twenty one full-term pregnant patients who were admitted to the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, confirmed SARS-CoV-2 infection and COVID-2019 with laboratorial and clinical methods, were reviewed by our medical team, and the data were collected from January 20, 2020 to February 29, 2020. Main clinical data collection Clinical data had been collecting using a standard case report form, such as epidemiological history, clinical manifestations, auxiliary examination of major laboratory and clinic, etc. All the information was collected and confirmed by our medical team. Results Twenty one full-term pregnant patients were reviewed (median age 29 years), and no patients were admitted to intensive care unit (ICU), and died during the treating progress. According to our review, all the cases were infected by human to human transmission, and the most common symptoms at onset of illness were cough in 17 (80.95%), fatigue in 10 (47.62%), fever in 7 (33.33%), expectoration in 1 (4.76%), and only one patient (4.76%) developed shortness of breath on admission. The median time from exposure to onset of illness was 10 days (interquartile range 7 –2 days), and from onset of symptoms to first hospital admission was 1 day (interquartile range 1–2 days). Conclusions As of February 29, 2020, all the patients who were full-term pregnancy combined with COVID-2019 were cured and delivered successfully, and all the newborns were not infected with SARS-CoV-2, and there were no evidence of mother-to-child transmission. |
7/21/2020 | 7/23/2020 | https://link.springer.com/article/10.1007/s00404-020-05573-8 | China | Descriptive study | Chen Y, Bai J. | Arch Gynecol Obstet | 2020 | Peer-reviewed | 10.1007/s00404-020-05573-8 | English | Yes | Yes | Yes | LMIC | 21 pts | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Current week | |||||||||||
| An infant with coronavirus disease 2019 in China: A case report | Rationale: In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, China. The initial epidemiological investigations showed that COVID-19 occurred more likely in adults, with patients younger than 10 years old accounting for less than 1% of the total number of confirmed cases, and infant infections were more rare. In our case, we present an infant who was only 35 days old when he was tested positive for COVID-19. Patient concerns: In this report, a 35 day-old male infant with atypical symptoms had close contact with 2 confirmed patients of COVID-19 who were his grandmother and mother. Diagnosis: The patient was diagnosed as COVID-19 after his oropharyngeal swab tested positive for severe acute respiratory syndrome coronavirus 2 by reverse transcription-polymerase chain reaction assay. Interventions: The therapeutic schedule included aerosol inhalation of recombinant human interferon α-2b and supportive therapy. Outcomes: Two consecutive (1 day apart) oropharyngeal swabs tested negative for severe acute respiratory syndrome coronavirus 2; then, the patient was discharged on February 27, 2020. Lessons: Strengthening infants’ virus screening in families with infected kins is important for early diagnosis, isolation, and treatment when symptoms are atypical. The infectivity of infants with mild or asymptomatic COVID-19 should not be ignored because this may be a source of transmission in the community. |
7/17/2020 | 7/25/2020 | https://journals.lww.com/md-journal/FullText/2020/07170/An_infant_with_coronavirus_disease_2019_in_China_.131.aspx | China | Descriptive study | Cao W, Mai G, Liu Z, Ren H. | Medicine (Baltimore) | 2020 | Peer-reviewed | 10.1097/MD.0000000000021359 | English | Yes | LMIC | 1 | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Sleep of preschoolers during the coronavirus disease 2019 (COVID-19) outbreak | Coronavirus disease 2019 (COVID‐19) has resulted in a significantly large number of psychological consequences, including sleep health. The present study evaluated sleep patterns, sleep disturbances, and associated factors in Chinese preschoolers confined at home during the COVID‐19 outbreak. Caregivers of 1619 preschoolers (aged 4–6 years) recruited from 11 preschools in Zunyi, Guizhou province completed the Children’s Sleep Habit Questionnaire (CSHQ) between 17th and 19th February 2020. Data were compared to a sociodemographically similar sample of preschoolers (included in the 11 preschools) in 2018. Compared to the 2018 sample, the confined preschoolers demonstrated changes in sleep patterns characterized by later bedtimes and wake times, longer nocturnal and shorter nap sleep durations, comparable 24‐hr sleep duration, and fewer caregiver‐reported sleep disturbances. Moreover, behavioural practices (sleeping arrangement, reduced electronic device use, regular diet) and parenting practices (harmonious family atmosphere and increased parent‐child communication) were associated with less sleep disturbances in the confined sample. The present study provides the first description of the impact of prolonged home confinement during the COVID‐19 outbreak on sleep patterns and sleep disturbances in preschoolers, as well as highlighting the importance of the link between sleep health and family factors. Given that disrupted and insufficient sleep has been linked to immune system dysfunction, our findings also have potential implications for resilience to infection in young children during the COVID‐19 pandemic. Future studies should further explore deficient sleep as a risk factor for coronavirus infection. | 7/27/2020 | 7/28/2020 | https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.13142 | China | Cross-sectional study | Liu Z, Tang H, Jin Q, Wang G, Yang Z, Chen H, Yan H, Rao W, Owens J. | J Sleep Res | 2020 | Peer-reviewed | 10.1111/jsr.13142 | English | Yes | Yes | LMIC | 11 preschools (n=1619) | Yes | Yes | Yes | Current week | ||||||||||||||||
| Indoor air pollution (IAP) and pre-existing morbidities among under-5 children in India: are risk factors of coronavirus disease (COVID-19)? | Globally, the Coronavirus disease (COVID-19) outbreak is linked with air pollution of both indoor and outdoor environments and co-morbidities conditions of human beings. To find out the risk factor zones associated with Coronavirus disease among under-five children using pre-existing morbidity conditions and indoor air pollution (IAP) environmental factors and also with current fatality and recovery rate of COVID-19 disease in India. Data was utilized from the 4th round of the National Family Health Survey (NFHS), 2015–16, and from the Ministry of Health and Family Welfare (MoHFW) on 18th May 2020. Mean, standard deviation, and Z-score statistical methods have been employed to find out the risk factor zones i.e. to execute the objective. Findings of this study are, the states and UTs which have more likely to very higher to higher risk factors or zones of Coronavirus disease (COVID-19) are Mizoram (1.4), Meghalaya (1.27), Uttarakhand (0.92), West Bengal (0.73), Uttar Pradesh (0.66), Jammu and Kashmir (0.44), Odisha (0.33), Madhya Pradesh (0.21), Jharkhand (0.20), Bihar (0.19), Maharashtra (0.16 risk score), compared to UTs like Assam (-0.12), Rajasthan (-0.13), Goa (-0.14), Manipur (-0.17), Chandigarh (-0.19), Haryana (-0.22), Delhi (-0.27) have moderate risk factors of COVID-19, and the states and UTs like Daman and Diu (-1.18), Sikkim (-0.98), Andaman and Nicobar Islands (-0.84), Kerala (-0.69), Dadra and Nagar Haveli (-0.68), Arunachal Pradesh ( 0.-53), Karnataka (-0.42), and Nagaland (-0.36) have very low-risk zones of COVID-19 deaths. From a research viewpoint, there is a prerequisite need for epidemiological studies to investigate the connection between indoor air pollution and pre-existing morbidity which are associated with COVID-19. Well-built public health measures, including rapidly searching in high focus areas and testing of COVID-19, should be performed in vulnerable areas of COVID-19. | 7/15/2020 | 7/22/2020 | https://www.sciencedirect.com/science/article/pii/S026974912033966X?via%3Dihub | India | Cohort study | Saha J, Chouhan P. | Environ Pollut | 2020 | Peer-reviewed | 10.1016/j.envpol.2020.115250 | English | Yes | LMIC | Not applicable | Yes | Yes | Yes | Current week | |||||||||||||||||
| Parents' Stress and Children's Psychological Problems in Families Facing the COVID-19 Outbreak in Italy | Objectives: The present study aimed to explore the effect of risk factors associated with the COVID-19 outbreak experience on parents' and children's well-being. Methods: Parents of children aged between 2- and 14-years-old completed an online survey reporting their home environment conditions, any relation they had to the pandemic consequences, their difficulties experienced due to the quarantine, their perception of individual and parent-child dyadic stress, and their children's emotional and behavioral problems. Results: Results showed that the perception of the difficulty of quarantine is a crucial factor that undermines both parents' and children's well-being. Quarantine's impact on children's behavioral and emotional problems is mediated by parent's individual and dyadic stress, with a stronger effect from the latter. Parents who reported more difficulties in dealing with quarantine show more stress. This, in turn, increases the children's problems. Living in a more at-risk area, the quality of the home environment, or the relation they have with the pandemic consequences, do not have an effect on families' well-being. Conclusions: Dealing with quarantine is a particularly stressful experience for parents who must balance personal life, work, and raising children, being left alone without other resources. This situation puts parents at a higher risk of experiencing distress, potentially impairing their ability to be supportive caregivers. The lack of support these children receive in such a difficult moment may be the reason for their more pronounced psychological symptoms. Policies should take into consideration the implications of the lockdown for families' mental health, and supportive interventions for the immediate and for the future should be promoted. |
7/3/2020 | 7/29/2020 | https://www.frontiersin.org/articles/10.3389/fpsyg.2020.01713/full#h1 | Italy | Cross-sectional study | Spinelli M, Lionetti F, Pastore M, Fasolo M. | Front Psychol | 2020 | Peer-reviewed | 10.3389/fpsyg.2020.01713 | English | Yes | HIC | 271 | Yes | Yes | Mental health | Current week | |||||||||||||||||
| Psychological burden of quarantine in children and adolescents: A rapid systematic review and proposed solutions | As COVID-19 grips the world, many people are quarantined or isolated resulting in adverse consequences for the mental health of youth. This rapid review takes into account the impact of quarantine on mental health of children and adolescents, and proposes measures to improve psychological outcomes of isolation. Three electronic databases including PubMed, Scopus, and ISI Web of Science were searched. Two independent reviewers performed title and abstract screening followed by full-text screening. This review article included 10 studies. The seven studies before onset of COVID 19 about psychological impact of quarantine in children have reported isolation, social exclusion stigma and fear among the children. The most common diagnoses were acute stress disorder, adjustment disorder, grief, and post-traumatic stress disorder. Three studies during the COVID-19 pandemic reported restlessness, irritability, anxiety, clinginess and inattention with increased screen time in children during quarantine. These adverse consequences can be tackled through carefully formulated multilevel interventions. | 6/26/2020 | 7/25/2020 | https://www.pjms.org.pk/index.php/pjms/article/view/3088 | Multicountry | Review | Imran N, Aamer I, Sharif MI, Bodla ZH, Naveed S. | Pak J Med Sci | 2020 | Peer-reviewed | 10.12669/pjms.36.5.3088 | English | Yes | Yes | LMIC/HIC | 10 studies | Yes | Yes | Mental health | Current week | ||||||||||||||||
| SARS-CoV-2 Causes Kawasaki like Disease in children; Cases reported in Pakistan | None available | 7/24/2020 | 7/25/2020 | https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26340 | Pakistan | Editorial/commentary/guidance | Khan KS, Ullah I. | J Med Virol | 2020 | Peer-reviewed | 10.1002/jmv.26340 | English | Yes | LMIC | Not applicable | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Clinical Molecular Genetics Evaluation in Women with Reproductive Failures | Molecular diagnostics is a rapidly growing branch of the clinical laboratory and has accelerated the advance of personalized medicine in the fields of pharmacogenomics, pharmacogenetics, and nutrigenomics. The versatility of molecular biology allows it to be effective in several medical fields that include reproduction, immunogenetics and virology. Implementation of molecular and sequencing technology in reproductive medicine can add another layer of understanding to better define the causes behind infertility and recurrent reproductive loss. In the following we examine current molecular methods for probing factors behind reproductive pregnancy loss including reverse transcription PCR (RT‐PCR), and Next Generation Sequencing (NGS). We review several current and potential genetic (DNA) and transcriptional (RNA) based parameters in women with infertility that can be significant in diagnosis and treatment. These molecular factors can be inferred either from genomic DNA, or RNA locally within the endometrium. Furthermore, we consider infection‐based abnormalities such as Human Herpes Virus‐6 (HHV‐6), and Severe acute respiratory syndrome coronavirus‐2 (SARS CoV‐2). Finally, we present future directions as well as data demonstrating the potential role of Human Endogenous Retroviruses (HERV) in pregnancy loss. We hope these discussions will assist the clinician in delineating some of the intricate molecular factors that can contribute to infertility and recurrent reproductive failures. | 7/25/2020 | 7/26/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.13313 | USA | Editorial/commentary/guidance | Bilal MY, Katara G, Dambaeva S, Kwak-Kim J, Gilman-Sachs A, Beaman KD. | Am J Reprod Immunol | 2020 | Peer-reviewed | 10.1111/aji.13313 | English | Yes | Yes | HIC | Not applicable | Yes | Yes | Yes | Yes | Current week | |||||||||||||||
| Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study | Background The risk of vertical and perinatal transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, which causes COVID-19), the most appropriate management, and the neonate's risk of developing COVID-19 during the perinatal period are unknown. Therefore, we aimed to elucidate best practices regarding infection control in mother–newborn dyads, and identify potential risk factors associated with transmission. Methods In this observational cohort study, we identified all neonates born between March 22 and May 17, 2020, at three New York Presbyterian Hospitals in New York City (NY, USA) to mothers positive for SARS-CoV-2 at delivery. Mothers could practice skin-to-skin care and breastfeed in the delivery room, but had to wear a surgical mask when near their neonate and practice proper hand hygiene before skin-to-skin contact, breastfeeding, and routine care. Unless medically required, neonates were kept in a closed Giraffe isolette in the same room as their mothers, and were held by mothers for feeding after appropriate hand hygiene, breast cleansing, and placement of a surgical mask. Neonates were tested for SARS-CoV-2 by use of real-time PCR on nasopharyngeal swabs taken at 24 h, 5–7 days, and 14 days of life, and were clinically evaluated by telemedicine at 1 month of age. We recorded demographics, neonatal, and maternal clinical presentation, as well as infection control practices in the hospital and at home. Findings Of 1481 deliveries, 116 (8%) mothers tested positive for SARS-CoV-2; 120 neonates were identified. All neonates were tested at 24 h of life and none were positive for SARS-CoV-2. 82 (68%) neonates completed follow-up at day 5–7 of life. Of the 82 neonates, 68 (83%) roomed in with the mothers. All mothers were allowed to breastfeed; at 5–7 days of life, 64 (78%) were still breastfeeding. 79 (96%) of 82 neonates had a repeat PCR at 5–7 days of life, which was negative in all; 72 (88%) neonates were also tested at 14 days of life and none were positive. None of the neonates had symptoms of COVID-19. Interpretation Our data suggest that perinatal transmission of COVID-19 is unlikely to occur if correct hygiene precautions are undertaken, and that allowing neonates to room in with their mothers and direct breastfeeding are safe procedures when paired with effective parental education of infant protective strategies. |
7/23/2020 | 7/27/2020 | https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(20)30235-2/fulltext | USA | Cohort study | Salvatore CM, Han JY, Acker KP, Tiwari P, Jin J, Brandler M, Cangemi C, Gordon L, Parow A, DiPace J, DeLaMora P. | Lancet Child Adolesc Health | 2020 | Peer-reviewed | 10.1016/S2352-4642(20)30235-2 | English | Yes | Yes | Yes | HIC | 116 mothers, 120 neonates | Yes | Yes | Yes | Yes | Yes | Yes | Yes | All mothers were allowed to breastfeed; at 5–7 days of life, 64 (78%) were still breastfeeding. | Breast milk/ Breast feeding | Current week | |||||||||
| [Review of new evidence about the possible vertical transmission of coronavirus disease-2019] | Abstract Objective To conduct a systematic review of original peer-reviewed studies, containing data on the identification of SARS-CoV-2 in clinical samples of amniotic fluid, placenta or membranes, umbilical cord blood, and human milk, from women with a clinically or confirmed diagnosis of COVID-19. These studies should have been published after the guide for the management of patients with COVID-19 from World Health Organization guide (available in March 13, 2020). Results Seventeen studies were included, in which 143 clinical samples were identified (38 of amniotic fluid; 34 of placentas or membranes; 39 from umbilical cord blood and 32 from human milk). Among the 143 samples, nine were positive for SARS-CoV-2 RNA (one amniotic fluid sample obtained before rupturing the membranes; six samples of placenta or membranes, although authors indicate the possibility of contamination by maternal blood in three of these, and two samples of human milk). Conclusions Following our search criteria, we found no studies that demonstrate the detection of SARS-CoV-2, in conjunction with viral isolation and the evaluation of the infective capacity of viral particles, in clinical samples of amniotic fluid, placenta or membranes, umbilical cord blood and human milk, from women with a confirmed or clinical diagnosis of COVID-19. However, vertical transmission cannot be ruled out, larger studies are required that ideally locate in situ RNA and protein of SARS-CoV-2, as well as isolation that demonstrate the infective capacity of the viral particles. |
6/20/2020 | 7/27/2020 | https://www.sciencedirect.com/science/article/pii/S0213911120301370?via%3Dihub | Multicountry | Review | Sampieri CL, Montero H. | Gac Sanit | 2020 | Peer-reviewed | 10.1016/j.gaceta.2020.06.005 | Spanish | Yes | Yes | LMIC/HIC | 17 studies | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| Obstetric and intensive-care strategies in a high-risk pregnancy with critical respiratory failure due to COVID-19: A case report | Background With the disease burden increasing daily, there is a lack of evidence regarding the impact of COVID-19 in pregnancy. Healthy pregnant women are still not regarded as a susceptible group despite physiological changes that make pregnant women more vulnerable to severe infection. However, high-risk pregnancies may be associated with severe COVID-19 disease with respiratory failure, as outlined in this report. We discuss the importance of timely delivery and antenatal steroid administration in a critically ill patient. Case A 27-year-old pregnant woman (gravida 2, para 1) with type I diabetes, morbid obesity, hypothyroidism and a previous Caesarean section presented with critical respiratory failure secondary to COVID-19 at 32 weeks of gestation. A preterm emergency Caesarean section was performed, after steroid treatment for foetal lung maturation. The patient benefited from prone positioning; however, transient acute renal injury, rhabdomyolysis and sepsis led to prolonged intensive care and mechanical ventilation for 30 days. The baby had an uncomplicated recovery. Conclusion COVID-19 infection in high-risk pregnancies may result in severe maternal and neonatal outcomes such as critical respiratory failure requiring mechanical ventilation and premature termination of the pregnancy. Antenatal steroids may be of benefit for foetal lung maturation but should not delay delivery in severe cases. |
7/8/2020 | 7/28/2020 | https://www.sciencedirect.com/science/article/pii/S2214911220300709?via%3Dihub | Sweden | Descriptive study | Kolkova Z, Bjurström MF, Länsberg JK, Svedas E, Hamer MA, Hansson SR, Herbst A, Zaigham M. | Case Rep Womens Health | 2020 | Peer-reviewed | 10.1016/j.crwh.2020.e00240 | English | Yes | HIC | 1 | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Worldwide maternal deaths due to COVID-19: A brief review | After initial studies suggested that pregnant women were not at a higher risk of complications due to COVID‐19 infection[1], recent investigations from Sweden and the US have indicated that pregnant and postpartum women are at increased risk of severe complications associated with COVID‐19.[2, 3] In an analysis of 8207 cases of COVID‐19 in the obstetric population, the Centers For Disease Control and Prevention (CDC) reported a higher risk of ICU admission and mechanical ventilation compared to non‐pregnant women, although no higher risk of mortality was identified.[3] | 7/24/2020 | 7/25/2020 | https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.13328 | USA | Cohort study | Nakamura-Pereira M, Andreucci CB, de Oliveira Menezes M, Knobel R, Takemoto MLS. | Int J Gynaecol Obstet | 2020 | Peer-reviewed | 10.1002/ijgo.13328 | English | Yes | Yes | HIC | 8207 | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| Child and adolescent mental illness during COVID-19: A rapid review | None available | 7/16/2020 | 7/25/2020 | https://www.sciencedirect.com/science/article/pii/S0165178120323702?via%3Dihub | Multicountry | Review | Racine N, Cooke JE, Eirich R, Korczak DJ, McArthur B, Madigan S. | Psychiatry Res | 2020 | Peer-reviewed | 10.1016/j.psychres.2020.113307 | English | Yes | Yes | LMIC/HIC | 6 studies | Yes | Yes | Mental health | Current week | ||||||||||||||||
| Coronavirus in pregnancy and delivery in Japan | None available | 6/2/2020 | 7/23/2020 | https://www.tandfonline.com/doi/full/10.1080/14767058.2020.1793942 | Japan | Descriptive study | Owada M, Suzuki S. | J Matern Fetal Neonatal Med | 2020 | Peer-reviewed | 10.1080/14767058.2020.1793942 | English | Yes | HIC | Not applicable | Current week | ||||||||||||||||||||
| Shoring up the safety net for children in the COVID-19 pandemic | None available | 7/26/2020 | 7/27/2020 | https://www.nature.com/articles/s41390-020-1071-7 | Multicountry | Editorial/commentary/guidance | Cheng TL, Moon M, Artman M; Pediatric Policy Council. | Pediatr Res | 2020 | Peer-reviewed | 10.1038/s41390-020-1071-7 | English | Yes | LMIC/HIC | Not applicable | Yes | Current week | |||||||||||||||||||
| COVID-19 fears may widen gaps in early pregnancy care | None available | 7/27/2020 | 7/29/2020 | https://www.cmaj.ca/content/192/30/E870 | Canada | Editorial/commentary/guidance | Comeau N. | CMAJ | 2020 | Peer-reviewed | 10.1503/cmaj.1095885 | English | Yes | Yes | HIC | Not applicable | Yes | Yes | Yes | Yes | Current week | |||||||||||||||
| Pregnancy, birth, and puerperium with SARS-CoV-2 and COVID-19 | With the pandemic spread of the novel coronavirus SARS-CoV ‑ 2, extensive measures to prevent infection have been taken worldwide. The crisis-oriented adjustment of the health system focused on a drastic reduction in electrical diagnostics and interventions to ensure the maintenance of critical care structures. Since prenatal and obstetrical medicine can only follow an elective framework to a very limited extent, the care of pregnant women and women giving birth with their partners and families has a special position. Gynecological practices, clinics and midwifery care face considerable challenges. In the following, the special features of the SARS-CoV-2 infection and the COVID-19 disease in pregnancy, childbirth and the puerperium with current recommendations for action are presented based on the data available (as of literature May 30, 2020, CRONOS database June 26, 2020). |
7/13/2020 | 7/22/2020 | https://link.springer.com/article/10.1007%2Fs00129-020-04637-9 | Germany | Review | Hagenbeck C., Pecks U., Fehm T., Borgmeier F., Schleußner E., Zöllkau J. | Gynakologe (2020). Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1007/s00129-020-04637-9 | German | Yes | Yes | HIC | Not applicable | Yes | Yes | Yes | Yes | Yes | Current week | ||||||||||||||
| Pandemic-related pregnancy stress and anxiety among women pregnant during the coronavirus disease 2019 pandemic | None available | 6/15/2020 | 7/23/2020 | https://www.sciencedirect.com/science/article/pii/S2589933320300999?via%3Dihub | USA | Cross-sectional study | Preis H., Mahaffey B., Heiselman C., Lobel M. | American Journal of Obstetrics and Gynecology MFM (2020) Article Number: 100155. Date of Publication: 2020 | 2020 | Peer-reviewed | 10.1016/j.ajogmf.2020.100155 | English | Yes | Yes | HIC | 788 | Yes | Yes | Yes | Mental health | Current week | |||||||||||||||
| SARS-CoV-2 viral load in the upper respiratory tract of children and adults with early acute COVID-19 | The role of children in the transmission of SARS-CoV-2 is unclear. We analysed viral load at the time of diagnosis in 53 children vs. 352 adults with COVID-19 in the first 5 days post symptom onset. No significant differences in SARS-CoV-2 RNA loads were seen between children and adults.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe study was funded by the Swiss National Foundation (SNF number 31CA30_196732/1, C.A. Siegrist), the Fondation de Bienfaisance du Groupe Pictet and the Fondation privee des HUGAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The work was approved by the Cantonal ethics committee (no. 2020-00813; no. 2020-00835, no. 2020-00516). All study participants and/or their legal guardians provided written informed consent.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.Yesna | 7/17/2020 | 7/20/2020 | http://medrxiv.org/content/early/2020/07/19/2020.07.17.20155333.abstract | Switzerland | Cohort study | Baggio, SLH, Arnaud G.; Yerly, Sabine; Bellon, Mathilde; Wagner, No?mie; Rohr, Marie; Huttner, Angela; Blanchard-Rohner, G?raldine; Loevy, Natasha; Kaiser, Laurent; Jacquerioz, Fr?d?rique; Eckerle, Isabella | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.17.20155333 | English | Yes | HIC | 53 children | Yes | Yes | Current week | ||||||||||||||||||
| Prevalence of mask wearing in northern Vermont in response to SARS-CoV-2 | Mask wearing is integral to reducing the spread of SARS-CoV-2. Information on prevalence of face mask usage is required both to model disease spread and to improve compliance with mask usage through targeted messaging. We sought to (1) estimate the prevalence of mask usage in the most populous county of Vermont (Chittenden County;&gt;25% of state population) and to (2) assess the effect of age and sex on mask use. We monitored the entrances to eight different business types and visually assessed individuals? age, gender, and mask use from a distance. We collected 1004 observations from 16 May through 30 May 2020 as businesses began to reopen following an extended state-wide lock down. We analyzed these data using a Bayesian random effects logistic regression model. We found that overall 75.5% of individuals used a mask with significant effects of age and gender on mask usage. Females were more likely to wear masks than males (83.8%, n=488 vs. 67.6%, n=516 mask usage, respectively); the odds of a male wearing a mask was 53% that of the female odds. Across age groups, the elderly were most likely to wear a mask (91.4%, n=209) followed by young adults (74.8%, n=246), middle-aged adults (70.7%, n=519) and children (53.3%, n=30). The odds of an elderly person wearing a mask were 16.7 times that of a child, while the odds for young adults and middle-aged adults were ?3 times greater than a child. Highest mask usage was in elder females (96.3%, n=109) and lowest mask usage was in male children (43.8%, n=16).Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external funding was received.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Our study was purely observational without any interaction with human subjects. According to our university IRB guidelines, IRB approval was not required for an observational study (https://www.uvm.edu/rpo/determine-if-project-requires-irb-review). A request for an exemption was also made.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesWe have posted the data and code to a GitHub repository and will make these available publicly after the study has been published in a peer-reviewed journal.https://github.com/brianbeckage/Masks_covid19.git | 7/23/2020 | 7/27/2020 | http://medrxiv.org/content/early/2020/07/25/2020.07.23.20158980.abstract | USA | Descriptive study | Beckage, BB, Thomas; Beckage, Maegan E. | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.23.20158980 | English | Yes | HIC | 30 children | Yes | Yes | Current week | ||||||||||||||||||
| An Optimization Framework to Study the Balance Between Expected Fatalities due to COVID-19 and the Reopening of U.S. Communities | As communities reopen following shelter-in-place orders, they are facing two conflicting objectives. The first is to keep the COVID-19 fatality rate down. The second is to revive the U.S. economy and the livelihood of millions of Americans. In this paper, a team of researchers from the Center on Stochastic Modeling, Optimization, &amp; Statistics (COSMOS) at the University of Texas at Arlington, in collaboration with researchers from University of Texas Southwestern Medical Center and Harvard Medical School, has formulated a computationally-efficient optimization framework, referred to as COSMOS COVID-19 Linear Programming (CC19LP), to study the delicate balance between the expected fatality rate and the level of normalcy in the community. Given the disproportionate fatality characteristics of COVID-19 among those in different age groups or with an underlying medical condition or those living with crowding, the key to the CC19LP framework is a focus on "key contacts" that separate individuals at higher risk from the rest of the population. The philosophy of CC19LP lies in maximizing protection of key contacts, so as to shield high-risk individuals from infection. Given the lack of pharmaceutical solutions, i.e., a vaccine or cure, the CC19LP framework minimizes expected fatalities by optimizing the use of non-pharmaceutical interventions, namely COVID-19 testing; personal protective equipment; and social precautions, such as distancing, hand-washing, and face coverings. Low-risk individuals that are not key contacts, including most children, are unrestricted and can choose to participate in pre-pandemic normal activities, which eliminates the need for compliance across the entire population. Consequently, the CC19LP framework demonstrates optimal strategies for protecting high-risk individuals while reopening communities.Competing Interest StatementThe authors have declared no competing interest.Funding StatementN/AAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:IRB not applicable.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAn online tool for the optimization has been developed by the authors and is publicly available. Data on COVID-19 cases and fatalities were obtained from a publicly available website. Data for the optimization were generated via publicly available Census data and a Gallup poll.https://cosmos.uta.edu/projects/covid-19/https://ourworldindata.org/coronavirushttps://www.census.gov/data.htmlhttps://news.gallup.com/poll/304643/million-severe-risk-infected-covid.aspx | 7/16/2020 | 7/20/2020 | http://medrxiv.org/content/early/2020/07/20/2020.07.16.20152033.abstract | USA | Modelling study | Chen, VCPZ, Yuan; Fallahi, Alireza; Viswanatha, Amith; Ghasemi, Yasaman; Ohol, Nilabh S.; Rosenberger, Jay M.; Liu, Feng; Ju, Xinglong; Guild, Jeffrey B. | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.16.20152033 | English | Yes | HIC | Not applicable | Yes | Yes | CC19LP framework was motivated by the concept of taking care of yourself, so that you can continue to care for others [16]. In this concept, the vulnerable group only stays protected if associated caregivers remain healthy. The CC19LP framework is based on partitioning the population into three non-overlapping groups, listed below and described in Figure 1. Group 1: Sheltered high-risk individuals that can shelter-in-place with the assistance of key contact individuals in Group 2. Group 2: COVID-19 key contacts that simultaneously have a role in protecting high-risk individuals in Group 1 and cannot avoid interaction with the rest of the population in Group 3. Group 3: Unrestricted low-risk individuals that do not belong to Group 2. |
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| Impact of Restrictions on Parental Presence in Neonatal Intensive Care Units Related to COVID-19 | Objectives: To determine the relationship between the emergence of COVID-19 and neonatal intensive care unit (NICU) family presence as well as how NICU design affects these changes. Study Design: A cross-sectional survey from April 21 to 30, 2020. We queried sites regarding NICU demographics, NICU restrictions on parental presence, and changes in ancillary staff availability. Results: Globally, 277 facilities responded to the survey. NICU policies preserving 24/7 parental presence decreased (83% to 53%, p&lt;0.001) and of preserving full parental participation in rounds fell (71% to 32%, p&lt;0.001). Single family room design NICUs best preserved 24/7 parental presence after the emergence of COVID-19 (single family room 65%, hybrid-design 57%, open bay design 45%, p=.018). In all, 120 (43%) NICUs reported reductions in therapy services, lactation medicine, and/or social work support. Conclusions: Hospital restrictions have significantly limited parental presence for NICU admitted infants, although single family room design may attenuate this effect.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external funding was received for this work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Methodist Healthcare IRBAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAfter manuscript publication data ca be made available upon request. | 7/22/2020 | 7/27/2020 | http://medrxiv.org/content/early/2020/07/25/2020.07.22.20158949.abstract | USA | Descriptive study | Darcey-Mahoney, AW, Robert D.; Velasquez, Annalyn; Barrett, Tyson S.; Clark, Reese H.; Ahmad, Kaashif Aqeeb | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.22.20158949 | English | Yes | HIC | 277 | Yes | Yes | Yes | Yes | Current week | ||||||||||||||||
| Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China | Abstract Importance Several parameters driving the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear, including age-specific differences in infectivity and susceptibility, and the contribution of inapparent infections to transmission. Robust estimates of key time-to-event distributions remain scarce as well. Objective Illustrate SARS-CoV-2 transmission patterns and risk factors, and estimate key time-to-event distributions. Design, Setting, and Participants Individual-based data on 1,178 SARS-CoV-2 infected individuals and their 15,648 contacts identified by contact tracing monitoring over the period from January 13-April 02, 2020 were extracted from the notifiable infectious diseases reporting system in Hunan Province, China. Demographic characteristics, severity classification, exposure and travel history, and key clinical timelines were retrieved. Exposures Confirmed SARS-CoV-2 infection by positive polymerase chain reaction test result of respiratory samples, and exposure to SARS-CoV-2 infected individuals via household, relative, social, and other types of contacts. Main Outcomes and Measures The relative contribution of pre-symptomatic and asymptomatic transmission, key time-to-event parameters, and the effect of biological, demographic, and behavioral factors on SARS-CoV-2 infectivity and susceptibility were quantified. Results Among SARS-CoV-2 infected individuals, the estimated mean serial interval was 5.5 days (95%CI -5.0, 19.9) and the mean generation time was 5.5 days (95%CI 1.7, 11.6). Infectiousness was estimated to peak 1.8 days before symptom onset, with 95% of transmission events occurring between -7.6 days and 7.3 days from the date of symptom onset. The proportion of pre-symptomatic transmission was estimated at 62.5%, while a lower bound for the proportion of asymptomatic transmission was 3.5%. Infectiousness of SARS-CoV-2 was not significantly different between working-age adults (15-59 years old) and other age groups (0-14 years old: p-value=0.16; 60 years and over: p-value=0.33), whilst susceptibility to SARS-CoV-2 infection was estimated to increase with age (p-value=0.03). In addition, transmission risk was higher for household contacts (p-value&lt;0.001), but decreased in later generations of a cluster (second generation: OR=0.13, p-value&lt;0.001; generations 3-4: OR=0.05, p-value&lt;0.001, relative to generation 1) and for those exposed to infectors with a larger number of contacts (p-value=0.04). Conclusions and Relevance These findings support the contribution of children to transmission and the importance of pre-symptomatic transmission, in turn highlighting the importance of large-scale testing, contact tracing activities, and the use of personnel protective equipment during the COVID-19 pandemic.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNational Science Fund for Distinguished Young Scholars (No. 81525023), National Science and Technology Major Project of China (No. 2017ZX10103009-005, No. 2018ZX10713001-007, No. 2018ZX10201001-010), and Hunan Provincial Innovative Construction Special Fund: Emergency response to COVID-19 outbreak (No. 2020SK3012).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was approved by the Institutional review board from Hunan Provincial Center for Disease Control and Prevention (IRB#2020005). Data were deidentified, and informed consent was waived.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial r gistration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesIndividual-based data on 1,178 SARS-CoV-2 infected individuals and their 15,648 contacts identified by contact tracing monitoring over the period from January 13-April 02, 2020 were extracted from the notifiable infectious diseases reporting system in Hunan Province, China. Demographic characteristics, severity classification, exposure and travel history, and key clinical timelines were retrieved. | 7/23/2020 | 7/27/2020 | http://medrxiv.org/content/early/2020/07/24/2020.07.23.20160317.abstract | China | Cross-sectional study | Hu, SW, Wei; Wang, Yan; Litvinova, Maria; Luo, Kaiwei; Ren, Lingshuang; Sun, Qianlai; Chen, Xinghui; Zeng, Ge; Li, Jing; Liang, Lu; Deng, Zhihong; Zheng, Wen; Li, Mei; Yang, Hao; Guo, Jinxin; Wang, Kai; Chen, Xinhua; Liu, Ziyan; Yan, Han; Shi, Huilin; Chen, Zhiyuan; Zhou, Yonghong; Sun, Kaiyuan; Vespignani, Alessandro; Viboud, C?cile; Gao, Lidong; Ajelli, Marco; Yu, Hongjie | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.23.20160317 | English | Yes | LMIC | 1178 | Yes | Current week | |||||||||||||||||||
| Providing breastfeeding support during the COVID-19 pandemic: Concerns of mothers who contacted the Australian Breastfeeding Association | Concerns of mothers seeking breastfeeding support during the COVID-19 pandemic, and the experiences of Australian Breastfeeding Association (ABA) volunteers who assisted them, were explored via an online survey. Surveys were completed 16th March to 18th of May 2020 and described the COVID-19 related concerns of 340 individuals. One hundred and thirty six mothers (64%) sought support to protect their infants by continuing breastfeeding, increasing milk supply, or restarting breastfeeding. Mothers were commonly stressed, isolated and needing reassurance. Thirty four (10%) raised concerns about COVID-19 and breastfeeding safety. One hundred and twenty nine (61%) informed volunteers they were unable to access face-to-face health services because of fear or unavailability. Most common breastfeeding concerns were related to insufficient milk or weight gain, painful breasts, relactation, and reducing supplemental milk. Volunteers reported mothers were worried stress had reduced milk supply, that milk supply concerns were exacerbated by the inability to weigh infants, and that seeking medical treatment was being delayed. ABA volunteers stated they felt supported and confident assisting mothers while also expressing distress at mothers situation. ABAs role in emergency response should be recognised and national planning for infant and young child feeding in emergencies, must be urgently developed, funded, and implemented.Competing Interest StatementAll authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: all authors are volunteers with the Australian Breastfeeding Association.Funding StatementNo financial assistance or funding was received from any sources towards this article.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This research was determined to be exempt from the need for ethical review by the Western Sydney University Human Research Ethics Committee.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData is not publicly available. | 7/18/2020 | 7/20/2020 | http://medrxiv.org/content/early/2020/07/20/2020.07.18.20152256.abstract | Australia | Cross-sectional study | Hull, NK, Renee L.; Gribble, Karleen D. | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.18.20152256 | English | Yes | Yes | HIC | 340 | Yes | Yes | Yes | Yes | Yes | Breast milk/ Breast feeding | Current week | |||||||||||||
| Pediatric intensive care unit admissions for COVID-19: insights using state level data | Introduction Intensive care has played a pivotal role during the COVID-19 pandemic as many patients developed severe pulmonary complications. The availability of information in pediatric intensive care (PICUs) remains limited. The purpose of this study is to characterize COVID-19 positive admissions (CPAs) in the United States and to determine factors that may impact those admissions. Materials and Methods This is a retrospective cohort study using data from the COVID-19 dashboard virtual pediatric system containing information regarding respiratory support and comorbidities for all CPAs between March and April 2020. The state level data contained 13 different factors from population density, comorbid conditions and social distancing score. The absolute CPAs count was converted to frequency using the state's population. Univariate and multivariate regression analyses were performed to assess the association between CPAs frequency and endpoints. Results A total of 205 CPAs were reported by 167 PICUs across 48 states. The estimated CPAs frequency was 2.8 per million children. A total of 3,235 tests were conducted with 6.3% positive tests. Children above 11 years of age comprised 69.7% of the total cohort and 35.1% had moderated or severe comorbidities. The median duration of a CPA was 4.9 days [1.25-12.00 days]. Out of the 1,132 total CPA days, 592 [52.2%] were for mechanical ventilation. The inpatient mortalities were 3 [1.4%]. Multivariate analyses demonstrated an association between CPA's with greater population density [beta-coefficient 0.01, p&lt;0.01] and increased percent of children receiving the influenza vaccination [beta-coefficient 0.17, p=0.01]. Conclusions Inpatient mortality during PICU CPAs is relatively low at 1.4%. CPA frequency seems to be impacted by population density while characteristics of illness severity appear to be associated with ultraviolet index, temperature, and comorbidities such as Type 1 diabetes. These factors should be included in future studies using patient-level data.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis project was done with no specific support. The authors have no financial relationships relevant to this article to discloseAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study utilized only publicly available, deidentified, state-level data. As such, no institutional review board review or approval was sought.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesDeidentified individual participant data will be made available at https://figshare.com/articles/dataset/Pediatric_intensive_care_unit_admissions_for_COVID-19_insights_using_state-level_data/12693461https://figshare.com/articles/dataset/Pediatric_intensive_care_unit_admissions_for_COVID-19_insights_using_state-level_data/12693461 | 7/22/2020 | 7/27/2020 | http://medrxiv.org/content/early/2020/07/24/2020.07.22.20160226.abstract | USA | Ecological study | Loomba, RSV, Enrique G.; Farias, Juan S.; Bronicki, Ronald A.; Flores, Saul | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.22.20160226 | English | Yes | Yes | HIC | 272 institutions | Yes | Yes | Yes | Yes | Current week | |||||||||||||||
| Seroprevalence of SARS-CoV-2 antibodies in an entirely PCR-sampled and quarantined community after a COVID-19 outbreak - the CoNAN study | Background: Due to the substantial proportion of asymptomatic and mild courses many SARS-CoV-2 infections remain unreported. Therefore, assessment of seroprevalence may detect the real burden of disease. We aimed at determining and characterizing the rate of SARS-CoV-2 infections and the resulting immunity in a defined population. Methods: CoNAN is a population-based cohort study in the previously quarantined community Neustadt-am-Rennsteig, Germany six weeks after a SARS-CoV-2 outbreak with 49 cases identified by PCR screening of all 883 inhabitants. The primary objective of the study was to assess SARS-CoV-2 antibody seroconversion rate using six different IgG detecting immunoassays. Secondary objectives of the study were: i.) to determine the rate of seroconversion in children; ii.) to determine potential risk factors for symptomatic vs. asymptomatic Covid19 courses; iii.) to investigate the rate of virus persistence. Findings: We enrolled 626 participants (71% of the community population). All actual SARS-CoV-2 PCR tests were negative; while a total of 8.4% (52 of 620 tested) had antibodies against SARS-CoV-2 in at least two independent tests. Twenty of the antibody positive participants had previously a positive SARS-CoV-2 PCR. On the contrary, of those 38 participants with SARS-CoV-2 infection, only 20 (52.6%) were antibody positive. Interpretation: Several antibody tests conducted six weeks after an outbreak of SARS-CoV-2 did not detect all previously PCR-positive tested individuals. Cautious evaluation of antibody testing strategies to assess immunity against the infection is warranted.Competing Interest StatementSW received speakers fees from MSD and Infectopharm. SH received speakers fees from Pfizer, MSD and Astra Zeneca. TK speakers fees from Roche MP has participated in international advisory boards from Pfizer, Novartis, Basilea and Cubist and received speakers fees from the same companies. CB has participated in advisory boards from GSK and received speakers fees from Pfizer. All other authors do not report any conflict of interestClinical TrialDRKS00022416 (submitted)Funding StatementCoNAN was funded by the Thuringian Ministry for Economic Affairs, Science and Digital Society (TMWWDG).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was conducted according to the current version of the Declaration of Helsinki and has been approved by the institutional ethics committees of the Jena University Hospital and the respective data protection commissioner (approval number 2020-1776) and the ethics committee of the Thuringian chamber of physicians.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data that support the findings of this study are available from the corresponding author upon reasonable request after publication of the manuscript. | 7/15/2020 | 7/20/2020 | http://medrxiv.org/content/early/2020/07/17/2020.07.15.20154112.abstract | Germany | Cohort study | Weis, SS, Andre; Baier, Michael; Kiehntopf, Michael; Kamradt, Thomas; Kolanos, Steffi; Ankert, Juliane; Gloeckner, Stefan; Makarewicz, Oliwia; Hagel, Stefan; Bahrs, Christina; Kimmig, Aurelia; Proquitte, Hans; Guerra, Joel; Loeffler, Bettina; Pletz, Mathias W. | medRxiv | 2020 | Pre-print source | 10.1101/2020.07.15.20154112 | English | Yes | HIC | 58 children | Yes | Current week |
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