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                             Table of Contents
                                                No.                                                                                                                                                                                                                 Title                                                                                                                                                                                                                                          Page
                                                      1                                 PENGARUH KECEPATAN PENGADUKAN TERHADAP KARAKTERISTIK FISIK                                                                                                                                                                                                                                                                                                                                                                   1 - 8
                                                                                        MIKROSFER OVALBUMIN-ALGINAT DENGAN METODE AEROSOLISASI
                                                      2                                 KARAKTERISASI PRONIOSOM IBUPROFEN-SPAN 60-KOLESTEROL YANG                                                                                                                                                                                                                                                                                                                                                                  9 - 22
                                                                                        DIBUAT DENGAN PELARUT PROPANOL DAN FASE AIR GLISEROL 0,1% 
                                                      3                                 Aktivitas Antibakteri Sel Amobil Streptomyces griseus ATCC 10137 Dalam Matriks                                                                                                                                                                                                                                                                                                                                          23 - 30
                                                                                        Poliakrilamid terhadap Staphylococcus aureus ATCC 25923
                                                      4                                  KARAKTERISASI SEDIAAN, PELEPASAN DAN UJI PENETRASI NATRIUM                                                                                                                                                                                                                                                                                                                                                             31 - 50
                                                                                        DIKLOFENAK DENGAN SISTEM MIKROEMULSI DALAM GEL HPMC 4000
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                             Vol. 2 - No. 2 / 2013-12
                             TOC : 2, and page : 9 - 22 
                             KARAKTERISASI PRONIOSOM IBUPROFEN-SPAN 60-KOLESTEROL YANG DIBUAT DENGAN PELARUT
                             PROPANOL DAN FASE AIR GLISEROL 0,1% 
                             KARAKTERISASI PRONIOSOM IBUPROFEN-SPAN 60-KOLESTEROL YANG DIBUAT DENGAN PELARUT
                             PROPANOL DAN FASE AIR GLISEROL 0,1% 
                             Author :
                             Tutiek Purwanti | tutiek_purwanti@yahoo.com
                             Fakultas Farmasi
                             Dewi Melani Hariyadi | dewiffua96@yahoo.com
                             Fakultas Farmasi
                             Rio Pranata Hardjakusuma | rio_p@yahoo.com
                             Fakultas Farmasi
                             Abstract 
                             The aim of this study was to determine characteristic of ibuprofen which consist of  ibuprofen - Span 60 - cholesterol with
                             molar ratio 2:1:0,75, 2:1:1, and 2:1:1,25. There were three formula this study. Evaluation of each formula were included
                             by organoleptics (odor, colour, and consistency), proniosome morphology using light microscope, niosome morphology
                             using Scanning Electron Microscope (SEM), niosome size used Particle Analyzer, and drug entrapment. Results of
                             organoleptic tests were formula had propanol odor, white colour, and solid consistency. Evaluation used light microscope
                             at 1000x magnification showed spherical shapes that had light edges. The next observation was Scanning Electron
                             Microscope (SEM) up to 40000x magnification. Niosome size resulted 692 nm (formula I), 957,6 nm (formula II), and
                             1152,3 nm (formula III), for % drug entrapment, the result was 91,91 ± 1,12 (formula I), 88,41 ± 3,10 (formula II), and
                             89,84 ± 1,71 (formula III). The best formula was formula I because of smallest size, biggest entrapment, and high
                             homogenity than other formula.
                             Keyword : proniosome, ibuprofen, niosome, drug, entrapment, , 
                             Daftar Pustaka :
                             1.  Biju, S.S., Talegaonkar, S., Mishra, P.R., and Khar, R.K, (2006). Vesicular systems : An overview. . India : Indian
                             Journal of Pharmaceutical Sciences
                             2.  Chavan,P, (2011). Proniosomal Gel : A novel Approach for Transdermal Drug Delivery. India : . International Journal
                             of Pharmaceutical Research and Development
                              
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                          KARAKTERISASI PRONIOSOM  
             IBUPROFEN-SPAN 60-KOLESTEROL YANG DIBUAT DENGAN 
                PELARUT PROPANOL DAN FASE AIR GLISEROL 0,1%  
                    Tutiek Purwanti1*, Dewi Melani1, Rio Pranata Hardjakusuma1 
                  1Departemen Farmasetika, Fakultas Farmasi, Universitas Airlangga 
                        Jl. Dharmawangsa Dalam Selatan, Surabaya 60286 
                       *Corresponding author: tutiek_purwanti@yahoo.com 
            ABSTRACT 
                 The aim of this study was to determine characteristic of ibuprofen which consist 
            of  ibuprofen - Span 60 - cholesterol with molar ratio 2:1:0,75, 2:1:1, and 2:1:1,25. 
            There  were  three  formula  this  study.  Evaluation  of  each  formula  were  included  by 
            organoleptics  (odor,  colour,  and  consistency),  proniosome  morphology  using  light 
            microscope, niosome morphology using Scanning Electron Microscope (SEM), niosome 
            size used Particle Analyzer, and drug entrapment. Results of organoleptic tests were 
            formula had propanol odor, white colour, and solid consistency. Evaluation used light 
            microscope at 1000x magnification showed spherical shapes that had light edges. The 
            next  observation  was  Scanning  Electron  Microscope  (SEM)  up  to  40000x 
            magnification. Niosome size resulted 692 nm (formula I), 957,6 nm (formula II), and 
            1152,3 nm (formula III), for % drug entrapment, the result was 91,91 ± 1,12 (formula 
            I),  88,41 ± 3,10 (formula II), and 89,84 ± 1,71 (formula III). The best formula was 
            formula I because of smallest size, biggest entrapment, and high homogenity than other 
            formula. 
            Keywords (s):  Proniosome, Ibuprofen, Organoleptics, Drug Entrapment, Niosome 
                      Size. 
             
            ABSTRAK 
            Tujuan dari penelitian ini adalah untuk mengetahui karakteristik ibuprofen – span 60 – 
            kolesterol dengan perbandingan molar 2:1:0,75, 2:1:1, dan 2:1:1,25. Ada tiga formula 
            pada penelitian ini. Pada setiap formula dilakukan evaluasi, antara lain : organoleptis 
            (bau,  warna,  dan  konsistensi),  morfologi  proniosom  dengan  mikroskop  cahaya, 
            morfologi  niosom  dengan  Particle  Analyzer,  dan  uji  efisiensi  penjebakan.  Hasil  uji 
            organoleptis adalah formula yang memiliki bau propanol, warna putih, dan konsistensi 
            padat.  Morfologi  niosom  dengan  mikroskop  (1000x)  menunjukkan  bentuk  bulat. 
            Pengamatan berikutnya dengan Scanning Electron Microscope (SEM) hingga 40000x 
            pembesaran. Ukuran niosom menghasilkan 692 nm (formula I), 957,6 nm (formula II), 
            dan 1152,3 nm (formula III), untuk % efisiensi penjebakan diperoleh hasil 91,91 ± 1,12 
            (formula I), 88,41 ± 3,10 (formula II), and 89,84 ± 1,71 (formula III). Formula terbaik 
            adalah  formula  I  karena  memiliki  ukuran  terkecil,  efisiensi  penjebakan  terbesar 
            dibandingkan formula lainnya. 
            Kata Kunci : Proniosom, Ibuprofen, Organoleptis, Efisiensi Penjebakan, Ukuran 
                     niosom