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Table of Contents
No. Title Page
1 PENGARUH KECEPATAN PENGADUKAN TERHADAP KARAKTERISTIK FISIK 1 - 8
MIKROSFER OVALBUMIN-ALGINAT DENGAN METODE AEROSOLISASI
2 KARAKTERISASI PRONIOSOM IBUPROFEN-SPAN 60-KOLESTEROL YANG 9 - 22
DIBUAT DENGAN PELARUT PROPANOL DAN FASE AIR GLISEROL 0,1%
3 Aktivitas Antibakteri Sel Amobil Streptomyces griseus ATCC 10137 Dalam Matriks 23 - 30
Poliakrilamid terhadap Staphylococcus aureus ATCC 25923
4 KARAKTERISASI SEDIAAN, PELEPASAN DAN UJI PENETRASI NATRIUM 31 - 50
DIKLOFENAK DENGAN SISTEM MIKROEMULSI DALAM GEL HPMC 4000
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Vol. 2 - No. 2 / 2013-12
TOC : 2, and page : 9 - 22
KARAKTERISASI PRONIOSOM IBUPROFEN-SPAN 60-KOLESTEROL YANG DIBUAT DENGAN PELARUT
PROPANOL DAN FASE AIR GLISEROL 0,1%
KARAKTERISASI PRONIOSOM IBUPROFEN-SPAN 60-KOLESTEROL YANG DIBUAT DENGAN PELARUT
PROPANOL DAN FASE AIR GLISEROL 0,1%
Author :
Tutiek Purwanti | tutiek_purwanti@yahoo.com
Fakultas Farmasi
Dewi Melani Hariyadi | dewiffua96@yahoo.com
Fakultas Farmasi
Rio Pranata Hardjakusuma | rio_p@yahoo.com
Fakultas Farmasi
Abstract
The aim of this study was to determine characteristic of ibuprofen which consist of ibuprofen - Span 60 - cholesterol with
molar ratio 2:1:0,75, 2:1:1, and 2:1:1,25. There were three formula this study. Evaluation of each formula were included
by organoleptics (odor, colour, and consistency), proniosome morphology using light microscope, niosome morphology
using Scanning Electron Microscope (SEM), niosome size used Particle Analyzer, and drug entrapment. Results of
organoleptic tests were formula had propanol odor, white colour, and solid consistency. Evaluation used light microscope
at 1000x magnification showed spherical shapes that had light edges. The next observation was Scanning Electron
Microscope (SEM) up to 40000x magnification. Niosome size resulted 692 nm (formula I), 957,6 nm (formula II), and
1152,3 nm (formula III), for % drug entrapment, the result was 91,91 ± 1,12 (formula I), 88,41 ± 3,10 (formula II), and
89,84 ± 1,71 (formula III). The best formula was formula I because of smallest size, biggest entrapment, and high
homogenity than other formula.
Keyword : proniosome, ibuprofen, niosome, drug, entrapment, ,
Daftar Pustaka :
1. Biju, S.S., Talegaonkar, S., Mishra, P.R., and Khar, R.K, (2006). Vesicular systems : An overview. . India : Indian
Journal of Pharmaceutical Sciences
2. Chavan,P, (2011). Proniosomal Gel : A novel Approach for Transdermal Drug Delivery. India : . International Journal
of Pharmaceutical Research and Development
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KARAKTERISASI PRONIOSOM
IBUPROFEN-SPAN 60-KOLESTEROL YANG DIBUAT DENGAN
PELARUT PROPANOL DAN FASE AIR GLISEROL 0,1%
Tutiek Purwanti1*, Dewi Melani1, Rio Pranata Hardjakusuma1
1Departemen Farmasetika, Fakultas Farmasi, Universitas Airlangga
Jl. Dharmawangsa Dalam Selatan, Surabaya 60286
*Corresponding author: tutiek_purwanti@yahoo.com
ABSTRACT
The aim of this study was to determine characteristic of ibuprofen which consist
of ibuprofen - Span 60 - cholesterol with molar ratio 2:1:0,75, 2:1:1, and 2:1:1,25.
There were three formula this study. Evaluation of each formula were included by
organoleptics (odor, colour, and consistency), proniosome morphology using light
microscope, niosome morphology using Scanning Electron Microscope (SEM), niosome
size used Particle Analyzer, and drug entrapment. Results of organoleptic tests were
formula had propanol odor, white colour, and solid consistency. Evaluation used light
microscope at 1000x magnification showed spherical shapes that had light edges. The
next observation was Scanning Electron Microscope (SEM) up to 40000x
magnification. Niosome size resulted 692 nm (formula I), 957,6 nm (formula II), and
1152,3 nm (formula III), for % drug entrapment, the result was 91,91 ± 1,12 (formula
I), 88,41 ± 3,10 (formula II), and 89,84 ± 1,71 (formula III). The best formula was
formula I because of smallest size, biggest entrapment, and high homogenity than other
formula.
Keywords (s): Proniosome, Ibuprofen, Organoleptics, Drug Entrapment, Niosome
Size.
ABSTRAK
Tujuan dari penelitian ini adalah untuk mengetahui karakteristik ibuprofen – span 60 –
kolesterol dengan perbandingan molar 2:1:0,75, 2:1:1, dan 2:1:1,25. Ada tiga formula
pada penelitian ini. Pada setiap formula dilakukan evaluasi, antara lain : organoleptis
(bau, warna, dan konsistensi), morfologi proniosom dengan mikroskop cahaya,
morfologi niosom dengan Particle Analyzer, dan uji efisiensi penjebakan. Hasil uji
organoleptis adalah formula yang memiliki bau propanol, warna putih, dan konsistensi
padat. Morfologi niosom dengan mikroskop (1000x) menunjukkan bentuk bulat.
Pengamatan berikutnya dengan Scanning Electron Microscope (SEM) hingga 40000x
pembesaran. Ukuran niosom menghasilkan 692 nm (formula I), 957,6 nm (formula II),
dan 1152,3 nm (formula III), untuk % efisiensi penjebakan diperoleh hasil 91,91 ± 1,12
(formula I), 88,41 ± 3,10 (formula II), and 89,84 ± 1,71 (formula III). Formula terbaik
adalah formula I karena memiliki ukuran terkecil, efisiensi penjebakan terbesar
dibandingkan formula lainnya.
Kata Kunci : Proniosom, Ibuprofen, Organoleptis, Efisiensi Penjebakan, Ukuran
niosom
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