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Preeclampsia: a two stage disorder
Preeclampsia: a two stage disorder
Stage 1: Reduced Placental Stage 2: Maternal Syndrome
perfusion abnormal
implantation ???
Stage I
Stage I
Reduced placental perfusion
Placental Hypoperfusion in Preeclampsia
“... a diffuse hypoxia or relative maternal ischemia of the
placenta is the proximate or precipitating cause of
preeclampsia and the associated placental insufficiencies. “
Page 1948
Placental Hypoperfusion in Preeclampsia
evidence
Abnormal implantation
Association with microvascular diseases (diabetes,
hypertension etc.)
Association with large placentas (hydrops, multiple gestation,
hydatidiform mole)
Direct measurements (wash out and Doppler)
Animal models of preeclampsia
Spiral Arteries (non-pregnant)
Spiral Arteries (non-pregnant)
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